Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China.
Neurochem Res. 2023 Oct;48(10):2983-2995. doi: 10.1007/s11064-023-03962-4. Epub 2023 Jun 9.
Perioperative neurocognitive disorders (PND) increases postoperative dementia and mortality in patients and has no effective treatment. Although the detailed pathogenesis of PND is still elusive, a large amount of evidence suggests that damaged mitochondria may play an important role in the pathogenesis of PND. A healthy mitochondrial pool not only provides energy for neuronal metabolism but also maintains neuronal activity through other mitochondrial functions. Therefore, exploring the abnormal mitochondrial function in PND is beneficial for finding promising therapeutic targets for this disease. This article summarizes the research advances of mitochondrial energy metabolism disorder, inflammatory response and oxidative stress, mitochondrial quality control, mitochondria-associated endoplasmic reticulum membranes, and cell death in the pathogenesis of PND, and briefly describes the application of mitochondria-targeted therapies in PND.
围手术期神经认知障碍（PND）增加了患者术后痴呆和死亡的风险，且目前尚无有效的治疗方法。虽然 PND 的详细发病机制仍难以捉摸，但大量证据表明，受损的线粒体可能在 PND 的发病机制中发挥重要作用。健康的线粒体池不仅为神经元代谢提供能量，还通过其他线粒体功能维持神经元活动。因此，探索 PND 中线粒体功能异常有助于为该疾病找到有前途的治疗靶点。本文总结了线粒体能量代谢障碍、炎症反应和氧化应激、线粒体质量控制、线粒体相关内质网膜以及 PND 发病机制中细胞死亡的研究进展，并简要描述了线粒体靶向治疗在 PND 中的应用。
