Cain Veterinary Centre, Llansantffraid, UK.
Department of Livestock and One Health, Institute of Infection, Veterinary and Ecological Science, University of Liverpool, Neston, UK.
Vet Rec. 2023 Sep 20;193(6):e3116. doi: 10.1002/vetr.3116. Epub 2023 Jun 12.
This study reports the clinical cure rates of topical oxytetracycline and 10% zinc sulphate foot bathing for treatment of interdigital dermatitis (ID), footrot (FR) and contagious ovine digital dermatitis (CODD) in lambs.
The study was a randomised controlled trial of 75 lambs. Group A (n = 38) was foot bathed daily for 5 days in 10% zinc sulphate for 15 minutes and group B was treated with daily topical oxytetracycline for 5 days. On days 0, 7, 14, 28 and 42, lambs were scored for locomotion and foot lesions were recorded.
The initial cure rates for ID were 96.20% and 97.00%; for FR, 100% and 95%; and for CODD, 90.09% and 83.33% for zinc sulphate and oxytetracycline, respectively. By day 42, these had changed to 53.16% and 61% for ID; 47.82% and 70% for FR; and 100% and 83.33% for CODD. There were no significant differences in cure rates between the treatments for most time points.
The sample size was small, and further studies in larger cohorts and different classes of sheep are required before the findings can be translated into recommendations for clinical practice.
Both treatments achieved cure rates that are comparable to reported cure rates using systemic antibiotics and could be an effective alternative.
本研究报告了局部使用土霉素和 10%硫酸锌足浴治疗羔羊指间性皮炎(ID)、腐蹄病(FR)和传染性绵羊数字性皮炎(CODD)的临床治愈率。
这是一项针对 75 只羔羊的随机对照试验。A 组(n = 38)每天用 10%硫酸锌足浴 15 分钟,连续 5 天;B 组每天局部使用土霉素治疗,连续 5 天。在 0、7、14、28 和 42 天,对羔羊的运动和足部病变进行评分。
ID 的初始治愈率分别为 96.20%和 97.00%;FR 为 100%和 95%;CODD 为 90.09%和 83.33%,硫酸锌和土霉素的治愈率分别为 90.09%和 83.33%。到第 42 天,这两组的治愈率分别为 53.16%和 61%;FR 为 47.82%和 70%;CODD 为 100%和 83.33%。在大多数时间点,两种治疗方法的治愈率没有显著差异。
样本量较小,需要在更大的队列和不同种类的绵羊中进行进一步研究,才能将这些发现转化为临床实践的建议。
两种治疗方法的治愈率与报告的使用系统抗生素的治愈率相当,可能是一种有效的替代方法。