人下牙槽神经神经束膜细胞细胞连接中 JCAD 和 EGFR 的表达。
Expression of JCAD and EGFR in Perineurial Cell-Cell Junctions of Human Inferior Alveolar Nerve.
机构信息
Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.
Division of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan.
出版信息
J Histochem Cytochem. 2023 Jun;71(6):321-332. doi: 10.1369/00221554231182193. Epub 2023 Jun 13.
Although perineurium has an important role in maintenance of the blood-nerve barrier, understanding of perineurial cell-cell junctions is insufficient. The aim of this study was to analyze the expression of junctional cadherin 5 associated (JCAD) and epidermal growth factor receptor (EGFR) in the perineurium of the human inferior alveolar nerve (IAN) and investigate their roles in perineurial cell-cell junctions using cultured human perineurial cells (HPNCs). In human IAN, JCAD was strongly expressed in endoneurial microvessels. JCAD and EGFR were expressed at various intensities in the perineurium. In HPNCs, JCAD was clearly expressed at cell-cell junctions. EGFR inhibitor AG1478 treatment changed cell morphology and the ratio of JCAD-positive cell-cell contacts of HPNCs. Therefore, JCAD and EGFR may have a role in the regulation of perineurial cell-cell junctions.
虽然神经外膜在维持血-神经屏障方面起着重要作用，但对其细胞-细胞连接的了解还不够充分。本研究旨在分析连接钙黏附蛋白 5 相关 (JCAD) 和表皮生长因子受体 (EGFR) 在人下牙槽神经 (IAN) 神经外膜中的表达，并使用培养的人周围神经外膜细胞 (HPNC) 研究它们在神经外膜细胞-细胞连接中的作用。在人 IAN 中，JCAD 在神经内膜微血管中强烈表达。JCAD 和 EGFR 在神经外膜中的表达强度不同。在 HPNC 中，JCAD 清楚地表达在细胞-细胞连接处。EGFR 抑制剂 AG1478 处理改变了 HPNC 的细胞形态和 JCAD 阳性细胞-细胞接触的比例。因此，JCAD 和 EGFR 可能在调节神经外膜细胞-细胞连接中发挥作用。
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