评估纤维肌痛患者中性粒细胞-淋巴细胞比值、淋巴细胞-单核细胞比值和单核细胞-高密度脂蛋白比值，并确定其与疾病活动度、疼痛和抑郁程度的关系。

Evaluation of neutrophil-lymphocyte ratio, lymphocyte-monocyte, and monocyte-high density lipoprotein ratios in patients with fibromyalgia and determination of their relationship with disease activity, pain, and depression levels.

机构信息

Physical Medicine and Rehabilitation Department, Hitit University Erol Olcok Training and Research Hospital, Corum, Turkey.

出版信息

Eur Rev Med Pharmacol Sci. 2023 Jun;27(11):4929-4935. doi: 10.26355/eurrev_202306_32609.

DOI:10.26355/eurrev_202306_32609

PMID:37318466

Abstract

OBJECTIVE

This study aimed to evaluate neutrophil-lymphocyte ratio, lymphocyte-monocyte, and monocyte high-density lipoprotein ratios in patients with fibromyalgia and determine their relationship with disease activity, pain, and depression levels.

PATIENTS AND METHODS

This study was conducted with 40 healthy controls and 87 newly fibromyalgia (FM) diagnosed patients. Demographic characteristics, duration of pain, body mass index (BMI), and laboratory test results were recorded. The hematological indices and ratios were determined with a hemogram test. Disease activity was evaluated with a fibromyalgia impact questionnaire (FIQ). Depression status was evaluated with the beck depression inventory (BDI).

RESULTS

A total of 127 participants, 40 in the control group and 87 in the patient group, were included in the study. BMI values of the patient group were statistically higher than the control group (p=0.025). The white blood cell count of the patient group was statistically higher than the control group (p=0.007). Monocyte values were statistically higher in the patient group (p<0.001). Monocyte to high-density lipoprotein-cholesterol ratio (MHR) values in the patient group were statistically higher than the control group (p<0.001). Lymphocyte-monocyte-ratio (LMR) values of the control group were statistically higher than the patient group (p<0.001).

CONCLUSIONS

This study shows that in fibromyalgia patients, monocyte level and MHR were higher than in healthy subjects. Also, high-density lipoprotein-cholesterol (HDL-C) level was found lower, and the total cholesterol level was found higher in patients with FM. Increased LMR and HDL-C values were found as responsible for decreasing the risk of developing FM and increased glucose and total cholesterol values were responsible for increasing the risk of FM developing.

摘要

目的

本研究旨在评估纤维肌痛患者中性粒细胞与淋巴细胞比值、淋巴细胞与单核细胞比值以及单核细胞与高密度脂蛋白比值，并确定其与疾病活动度、疼痛和抑郁水平的关系。

患者与方法

本研究纳入了 40 名健康对照者和 87 名新诊断的纤维肌痛患者。记录了患者的人口统计学特征、疼痛持续时间、体重指数（BMI）和实验室检查结果。使用血液常规检查确定了血液学指标和比值。使用纤维肌痛影响问卷（FIQ）评估疾病活动度，使用贝克抑郁量表（BDI）评估抑郁状态。

结果

共纳入 127 名参与者，其中对照组 40 名，患者组 87 名。患者组的 BMI 值明显高于对照组（p=0.025）。患者组的白细胞计数明显高于对照组（p=0.007）。患者组的单核细胞计数明显较高（p<0.001）。患者组的单核细胞与高密度脂蛋白胆固醇比值（MHR）明显高于对照组（p<0.001）。对照组的淋巴细胞与单核细胞比值（LMR）明显高于患者组（p<0.001）。