铁介导的氧化级联[1+2+3]-环化/酯化反应：4-烷基化 1,4-二氢吡啶的合成。

Fe-mediated oxidative cascade [1 + 2 + 3]-cyclization/esterification reaction: synthesis of 4-alkylated 1,4-dihydropyridines.

机构信息

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, P. R. China.

College of Science, Honghe University, Mengzi 661199, P. R. China.

出版信息

Org Biomol Chem. 2023 Jul 5;21(26):5475-5480. doi: 10.1039/d3ob00704a.

DOI:10.1039/d3ob00704a

PMID:37341640

Abstract

An Fe-mediated four-component reaction of enaminones, anhydrides and tetrahydrofuran through a cascade [1 + 2 + 3]-cyclization/esterification process is presented. This protocol provides a new and effective method to construct 4-alkylated 1,4-dihydropyridines with an ester fragment. Cyclic ether is employed as the C4 source of 1,4-dihydropyridines for the first time.

摘要

本文报道了一种通过级联 [1 + 2 + 3]-环化/酯化过程，由烯胺酮、酸酐和四氢呋喃实现的 Fe 介导的四组分反应。该方案为构建具有酯基片段的 4-烷基取代的 1,4-二氢吡啶提供了一种新的有效方法。这是首次将环状醚作为 1,4-二氢吡啶的 C4 源使用。