埃氏泽兰醇 A-D，从泽兰中分离得到的四个新的橄榄苦苷衍生物及其对 LPS 激活的 RAW264.7 细胞中 NO 产生的抑制作用。
Elsholblanosides A-D, Four New Oleuropeic Acid Derivatives Isolated from Elsholtzia blanda and Their Inhibition of NO Production in LPS-activated RAW264.7 Cells.
机构信息
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Cau Giay, Hanoi, 10072, Vietnam.
出版信息
Chem Biodivers. 2023 Aug;20(8):e202300785. doi: 10.1002/cbdv.202300785. Epub 2023 Jul 6.
Phytochemical investigation on the aerial parts of Elsholtzia blanda Benth. afforded four new oleuropeic acid derivatives (1-4), named as elsholblanosides A-D, respectively, together with 11 known compounds (5-15). Their structures were determined based on extensive analyses of HR-ESI-MS, 1D and 2D NMR, and ECD spectra. Compounds 1-4 and 14 showed moderate NO production inhibition in LPS-activated RAW264.7 cells with their IC values ranging from 23.2 to 86.33 μM, compared to that of the positive control compound, dexamethasone, IC value of 16.9 μM.
从唇形科香薷属植物海州香薷（Elsholtzia blanda Benth.）的地上部分中分离得到四个新的橄榄苦苷类衍生物（1-4），分别命名为 elsholblanosides A-D，同时还分离得到了 11 个已知化合物（5-15）。根据高分辨电喷雾质谱（HR-ESI-MS）、一维和二维核磁共振（1D 和 2D NMR）以及圆二色谱（ECD）光谱等综合分析，确定了它们的结构。化合物 1-4 和 14 对 LPS 激活的 RAW264.7 细胞中 NO 的产生具有中等抑制作用，其 IC50 值范围为 23.2-86.33 μM，与阳性对照化合物地塞米松（dexamethasone）的 IC50 值 16.9 μM 相比。
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