Dysfunction of von-Hippel Lindau factor causes reduced degradation of HIF leading to renal cancer. Hypoxia-inducible factor-prolyl hydroxylase enzyme inhibitors also lessen HIF destruction and could therefore increase renal cancer.
作者信息
Waldum Helge
机构信息
Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
出版信息
Front Pharmacol. 2023 Jun 6;14:1170796. doi: 10.3389/fphar.2023.1170796. eCollection 2023.
Abstract
摘要
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Dysfunction of von-Hippel Lindau factor causes reduced degradation of HIF leading to renal cancer. Hypoxia-inducible factor-prolyl hydroxylase enzyme inhibitors also lessen HIF destruction and could therefore increase renal cancer.冯-希佩尔-林道因子功能障碍导致缺氧诱导因子（HIF）降解减少，进而引发肾癌。缺氧诱导因子-脯氨酰羟化酶抑制剂也会减少HIF的破坏，因此可能会增加肾癌的发生。
Front Pharmacol. 2023 Jun 6;14:1170796. doi: 10.3389/fphar.2023.1170796. eCollection 2023.
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