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由ATCC PTA - 127053(Xygest™ HT)生产的内切-1,4-β-木聚糖酶组成的饲料添加剂对所有家禽品种的功效(凯明欧洲公司)

Efficacy of a feed additive consisting of endo-1,4-beta-xylanase produced by ATCC PTA-127053 (Xygest™ HT) for all poultry species (Kemin Europa N.V.).

作者信息

Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Durjava Mojca, Dusemund Birgit, Kouba Maryline, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Ortuño Casanova Jordi

出版信息

EFSA J. 2023 Jun 21;21(6):e08047. doi: 10.2903/j.efsa.2023.8047. eCollection 2023 Jun.

Abstract

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the efficacy of endo-1,4-beta-xylanase produced by ATCC PTA-127053 (Xygest™ HT) as a zootechnical feed additive (functional group: digestibility enhancers) for all poultry. In a previous opinion, the FEEDAP Panel concluded that Xygest™ HT is safe for all poultry, consumers, and the environment. The additive is not considered to be irritant to eyes and skin but a dermal and a respiratory sensitiser, although exposure by inhalation is unlikely. The Panel also concluded that the additive has the potential to be efficacious in laying hens at 45,000 U/kg complete feed and this conclusion was extrapolated to all laying poultry. However, the Panel could not conclude on the efficacy of the product in growing poultry at the proposed conditions of use. In the current application, the applicant provided an additional efficacy trial in chickens for fattening. The results showed a higher apparent metabolisable energy (nitrogen corrected) in chickens fed the additive at the minimum proposed level of 30,000 U/kg complete feed when compared to the control group. Considering the previously submitted studies in laying hens and chickens for fattening, and the newly submitted study in chickens for fattening, the Panel concluded that Xygest™ HT has the potential to be efficacious to enhance digestibility in all poultry at the corresponding proposed minimum levels in feed.

摘要

应欧盟委员会的要求,欧洲食品安全局(EFSA)被要求就ATCC PTA - 127053(Xygest™ HT)产生的内切 - 1,4 - β - 木聚糖酶作为所有家禽的动物营养饲料添加剂(功能组:消化率增强剂)的功效发表科学意见。在之前的一份意见中,饲料添加剂和动物营养产品专家小组得出结论,Xygest™ HT对所有家禽、消费者和环境都是安全的。该添加剂虽不太可能通过吸入接触,但被认为对眼睛和皮肤无刺激性,不过是皮肤和呼吸道致敏剂。该小组还得出结论,该添加剂在蛋鸡完全饲料中添加量为45,000 U/kg时可能有效,这一结论外推至所有产蛋家禽。然而,该小组无法就该产品在拟议使用条件下对生长家禽的功效得出结论。在本次申请中,申请人提供了一项肉鸡育肥的额外功效试验。结果表明,与对照组相比,在完全饲料中添加最低拟议水平30,000 U/kg的该添加剂时,肉鸡的表观代谢能(氮校正)更高。考虑到之前提交的蛋鸡和肉鸡育肥研究,以及新提交的肉鸡育肥研究,该小组得出结论,Xygest™ HT在饲料中相应拟议的最低水平下,有可能有效提高所有家禽的消化率。

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Guidance on the assessment of the efficacy of feed additives.
EFSA J. 2018 May 7;16(5):e05274. doi: 10.2903/j.efsa.2018.5274. eCollection 2018 May.

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