Makibuchi Taiki, Yamashiro Koya, Anazawa Sayaka, Fujimoto Tomomi, Ochi Genta, Ikarashi Koyuki, Sato Daisuke
Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata 950-3198, Japan.
Field of Health and Sports, Graduate School of Niigata University of Health and Welfare, Niigata 950-3198, Japan.
Brain Sci. 2023 Jun 6;13(6):918. doi: 10.3390/brainsci13060918.
L-menthol is known to activate transient receptor potential melastatin 8 (TRPM8) and induce analgesia to thermal stimuli. However, since thermal stimulation leads to the interaction among the other TRP channels, it was unclear whether L-menthol causes analgesia to stimuli other than thermal stimuli. Therefore, we aimed to investigate whether activating TRPM8 via topical application of 10% menthol solution attenuates pain-related somatosensory-evoked potentials (pSEPs) and affects numerical rating scale (NRS) score using intra-epidermal electrical stimulation (IES). We applied 10% L-menthol or control solution on the dorsum of the right hand of 25 healthy participants. The pSEP and NRS, elicited by IES, and sensory threshold were measured before and after each solution was applied. The results showed that the topical application of 10% L-menthol solution significantly reduced N2-P2 amplitude in pSEPs compared with the control solution. Moreover, the N2 latency was significantly prolonged upon the topical application of L-menthol solution. NRS scores were similar under both conditions. These results suggest that topical application of L-menthol does not alter subjective sensation induced using IES, although it may attenuate afferent signals at free nerve endings even with stimuli that do not directly activate TRP channels.
众所周知，L-薄荷醇可激活瞬时受体电位香草酸亚型8（TRPM8）并诱导对热刺激产生镇痛作用。然而，由于热刺激会导致其他瞬时受体电位（TRP）通道之间相互作用，因此尚不清楚L-薄荷醇是否会对热刺激以外的其他刺激产生镇痛作用。因此，我们旨在研究通过局部应用10%薄荷醇溶液激活TRPM8是否会减弱疼痛相关的体感诱发电位（pSEP），并使用表皮内电刺激（IES）来评估数字评分量表（NRS）得分。我们将10%L-薄荷醇或对照溶液应用于25名健康参与者的右手背部。在每次应用溶液前后，测量由IES诱发的pSEP、NRS以及感觉阈值。结果显示，与对照溶液相比，局部应用10%L-薄荷醇溶液显著降低了pSEP中的N2-P2波幅。此外，局部应用薄荷醇溶液后，N2潜伏期显著延长。两种情况下的NRS得分相似。这些结果表明，局部应用L-薄荷醇不会改变使用IES诱发的主观感觉，尽管即使在不直接激活TRP通道的刺激下，它也可能减弱游离神经末梢的传入信号。
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