Department of Biomedicine, Health & Life Convergence Sciences (BK21 Four), Biomedical and Healthcare Research Institute (BHRI), Mokpo National University, Muan-gun 58554, Jeonnam, Republic of Korea.
Soft Hybrid Materials Research Center, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.
Biomolecules. 2023 Jun 1;13(6):929. doi: 10.3390/biom13060929.
Smart wearable patch systems that combine biosensing and therapeutic components have emerged as promising approaches for personalized healthcare and therapeutic platforms that enable self-administered, noninvasive, user-friendly, and long-acting smart drug delivery. Sensing components can continuously monitor physiological and biochemical parameters, and the monitoring signals can be transferred to various stimuli using actuators. In therapeutic components, stimuli-responsive carrier-based drug delivery systems (DDSs) provide on-demand drug delivery in a closed-loop manner. This review provides an overview of the recent advances in smart wearable patch systems, focusing on sensing components, stimuli, and therapeutic components. Additionally, this review highlights the potential of fully integrated smart wearable patch systems for personalized medicine. Furthermore, challenges associated with the clinical applications of this system and future perspectives are discussed, including issues related to drug loading and reloading, biocompatibility, accuracy of sensing and drug delivery, and largescale fabrication.
智能可穿戴贴片系统结合了生物传感和治疗组件，是个性化医疗和治疗平台的有前途的方法，这些平台可以实现自我管理、非侵入性、用户友好和长效智能药物输送。传感组件可以持续监测生理和生化参数，并且监测信号可以通过执行器传输到各种刺激。在治疗组件中，响应刺激的载体药物输送系统（DDS）以闭环方式按需提供药物输送。本综述概述了智能可穿戴贴片系统的最新进展，重点介绍了传感组件、刺激和治疗组件。此外，本综述强调了完全集成的智能可穿戴贴片系统在个性化医疗中的潜力。此外，还讨论了该系统临床应用相关的挑战和未来展望，包括与药物加载和再加载、生物相容性、传感和药物输送的准确性以及大规模制造相关的问题。
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