Ludwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA, 1200 Vienna, Austria.
Department of Biochemistry and Biotechnology, Precarpathian National University, 76000 Ivano-Frankivsk, Ukraine.
Biomolecules. 2023 Jun 8;13(6):966. doi: 10.3390/biom13060966.
Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies. We propose to refer to all diseases whose pathogenesis or progression is associated with cellular senescence as "senopathies". Targeting senescent cells with senolytics or senomorphics is likely to mitigate these pathologies. Examples of senopathies include cardiovascular, metabolic, musculoskeletal, liver, kidney, and lung diseases and neurodegeneration. For all these pathologies, animal studies provide clear mechanistic evidence for a connection between senescent cell accumulation and disease progression. The major persisting challenge in developing novel senotherapies is the heterogeneity of senescence phenotypes, causing a lack of universal biomarkers and difficulties in discriminating senescent from non-senescent cells.
细胞衰老描述了一种具有特征表型的稳定细胞周期停滞状态。衰老细胞在正常衰老过程中在人体内积累，限制了寿命并促进了与衰老相关的，但也有一些不相关的，病理。我们建议将所有其发病机制或进展与细胞衰老相关的疾病称为“衰老相关疾病”。用衰老细胞清除剂或衰老模拟物靶向衰老细胞可能会减轻这些病理。衰老相关疾病的例子包括心血管、代谢、肌肉骨骼、肝脏、肾脏和肺部疾病以及神经退行性变。对于所有这些疾病，动物研究为衰老细胞积累与疾病进展之间的联系提供了明确的机制证据。在开发新的衰老疗法方面，主要的持续挑战是衰老表型的异质性，导致缺乏普遍的生物标志物和难以区分衰老细胞和非衰老细胞。
