Viegas Cláudia, Patrício Ana B, Prata João M, Nadhman Akhtar, Chintamaneni Pavan Kumar, Fonte Pedro
Center for Marine Sciences (CCMar), University of Algarve, Gambelas Campus, 8005-139 Faro, Portugal.
Faculty of Medicine and Biomedical Sciences (FMCB), University of Algarve, Gambelas Campus, 8005-139 Faro, Portugal.
Pharmaceutics. 2023 May 25;15(6):1593. doi: 10.3390/pharmaceutics15061593.
Solid-lipid nanoparticles and nanostructured lipid carriers are delivery systems for the delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures. These nanocarriers may enhance the solubility and permeability of drugs, increase their bioavailability, and extend the residence time in the body, combining low toxicity with a targeted delivery. Nanostructured lipid carriers are the second generation of lipid nanoparticles differing from solid lipid nanoparticles in their composition matrix. The use of a liquid lipid together with a solid lipid in nanostructured lipid carrier allows it to load a higher amount of drug, enhance drug release properties, and increase its stability. Therefore, a direct comparison between solid lipid nanoparticles and nanostructured lipid carriers is needed. This review aims to describe solid lipid nanoparticles and nanostructured lipid carriers as drug delivery systems, comparing both, while systematically elucidating their production methodologies, physicochemical characterization, and in vitro and in vivo performance. In addition, the toxicity concerns of these systems are focused on.
固体脂质纳米粒和纳米结构脂质载体是用于递送药物和其他生物活性物质的给药系统，这些生物活性物质用于诊断、治疗及处置过程。这些纳米载体可提高药物的溶解度和渗透性，增加其生物利用度，并延长在体内的停留时间，兼具低毒性和靶向递送的特点。纳米结构脂质载体是第二代脂质纳米粒，在组成基质上与固体脂质纳米粒不同。在纳米结构脂质载体中使用液体脂质和固体脂质，使其能够负载更高量的药物，增强药物释放特性，并提高其稳定性。因此，需要对固体脂质纳米粒和纳米结构脂质载体进行直接比较。本综述旨在将固体脂质纳米粒和纳米结构脂质载体描述为药物递送系统，对两者进行比较，同时系统地阐明它们的生产方法、理化特性以及体外和体内性能。此外，还重点关注了这些系统的毒性问题。
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