Altuntaş Ebru, Özkan Burcu, Güngör Sevgi, Özsoy Yıldız
Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul University, 34116 Istanbul, Türkiye.
Graduate School of Natural and Applied Science, Yildiz Technical University, 34220 Istanbul, Türkiye.
Pharmaceutics. 2023 Jun 2;15(6):1644. doi: 10.3390/pharmaceutics15061644.
Due to their increased surface area, extent of swelling and active substance-loading capacity and flexibility, nanogels made from natural and synthetic polymers have gained significant interest in scientific and industrial areas. In particular, the customized design and implementation of nontoxic, biocompatible, and biodegradable micro/nano carriers makes their usage very feasible for a range of biomedical applications, including drug delivery, tissue engineering, and bioimaging. The design and application methodologies of nanogels are outlined in this review. Additionally, the most recent advancements in nanogel biomedical applications are discussed, with particular emphasis on applications for the delivery of drugs and biomolecules.
由于具有更大的表面积、溶胀程度、活性物质负载能力和柔韧性,由天然和合成聚合物制成的纳米凝胶在科学和工业领域引起了极大的关注。特别是,定制设计并实现无毒、生物相容和可生物降解的微/纳米载体,使得它们在一系列生物医学应用中非常可行,包括药物递送、组织工程和生物成像。本文综述了纳米凝胶的设计和应用方法。此外,还讨论了纳米凝胶生物医学应用的最新进展,特别强调了其在药物和生物分子递送方面的应用。