Conti Diego M, Hellings Peter W, Diamant Zuzana, Bjermer Leif, Jesenak Milos, Backer Vibeke, Fokkens Wytske, Lau Susanne, Van Staeyen Elizabeth, Scadding Glenis K
The European Forum for Research and Education in Allergy and Airway Diseases Scientific Expert Team Members, Brussels, Belgium.
KU Leuven Department of Microbiology and Immunology, Allergy and Clinical Immunology Research Unit, Leuven, Belgium.
Allergy Asthma Clin Immunol. 2023 Jun 30;19(1):56. doi: 10.1186/s13223-023-00816-0.
"Epidemiology of comorbidities and their association with asthma control" (Tomisa, G., Horváth, A., Sánta, B. et al. Epidemiology of comorbidities and their association with asthma control. Allergy Asthma Clin Immunol 17, 95 (2021). https://doi.org/10.1186/s13223-021-00598-3 ) is an interesting paper reflecting data collection from more than 12,000 asthmatic patients in Hungary regarding their condition and associated comorbidities. We found it valuable that the paper provides an overview of asthma comorbidities not usually considered in similar reports. Nevertheless, we believe that chronic rhinosinusitis (CRS) with or without nasal polyps (CRSwNP or CRSsNP) should have been listed due to its high incidence and prevalence, its association with asthma which is also endorsed in both GINA and EPOS, as well as in several peer-reviewed scientific papers, and to reflect the role of this comorbidity in poor control and a most severe presentation of asthma for the patient. Consequently, several targeted therapies (especially monoclonal antibodies) used for several years in severe forms of asthma are now indicated also for the effective treatment of nasal polyps.
《合并症的流行病学及其与哮喘控制的关联》(托米萨,G.,霍瓦特,A.,桑塔,B.等。合并症的流行病学及其与哮喘控制的关联。《过敏、哮喘与临床免疫学》17,95(2021年)。https://doi.org/10.1186/s13223-021-00598-3 )是一篇有趣的论文,反映了匈牙利12000多名哮喘患者的病情及相关合并症的数据收集情况。我们认为该论文提供了类似报告中通常未考虑的哮喘合并症概述,这很有价值。然而,我们认为无论有无鼻息肉的慢性鼻-鼻窦炎(CRSwNP或CRSsNP)都应被列出,因为其发病率和患病率高,与哮喘有关联(这在全球哮喘防治创议(GINA)和欧洲鼻窦炎和鼻息肉立场文件(EPOS)以及几篇同行评审的科学论文中均得到认可),并且能体现这种合并症在哮喘控制不佳和患者最严重哮喘表现中的作用。因此,目前一些多年来用于重度哮喘的靶向治疗药物(尤其是单克隆抗体)也被用于有效治疗鼻息肉。