Lei Xiaotian, Qiu Sheng, Yang Gangyi, Wu Qinan
Endocrinology Department, The Second Affiliated Hospital of the Chongqing Medical University, Chongqing 400000, China.
Endocrinology Department, The First Affiliated Hospital of the Army Medical University, Chongqing 400038, China.
Genes Dis. 2022 Nov 17;10(4):1525-1536. doi: 10.1016/j.gendis.2022.10.018. eCollection 2023 Jul.
Metabolic cardiovascular diseases have become a global health concern, and some of their risk factors are linked to several metabolic disorders. They are the leading causes of death in developing countries. Adipose tissues secrete a variety of adipokines that participate in regulating metabolism and various pathophysiological processes. Adiponectin is the most abundant pleiotropic adipokine and can increase insulin sensitivity, improve atherosclerosis, have anti-inflammatory properties, and exert a cardioprotective effect. Low adiponectin concentrations are correlated with myocardial infarction, coronary atherosclerotic heart disease, hypertrophy, hypertension, and other metabolic cardiovascular dysfunctions. However, the relationship between adiponectin and cardiovascular diseases is complex, and the specific mechanism of action is not fully understood. Our summary and analysis of these issues are expected to contribute to future treatment options.
代谢性心血管疾病已成为全球健康问题，其一些危险因素与多种代谢紊乱有关。它们是发展中国家的主要死因。脂肪组织分泌多种脂肪因子，参与调节代谢和各种病理生理过程。脂联素是最丰富的多效性脂肪因子，可提高胰岛素敏感性、改善动脉粥样硬化、具有抗炎特性并发挥心脏保护作用。脂联素浓度低与心肌梗死、冠状动脉粥样硬化性心脏病、肥大、高血压和其他代谢性心血管功能障碍相关。然而，脂联素与心血管疾病之间的关系很复杂，具体作用机制尚未完全了解。我们对这些问题的总结和分析有望为未来的治疗选择做出贡献。
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