Kakoi Hironaga, Kikuchi Mio, Ishige Taichiro, Hirosawa Yuko, Tanaka Shoko, Nagata Shun-Ichi
Laboratory of Racing Chemistry, Tochigi 320-0851, Japan.
National Livestock Breeding Center Tokachi Station, Hokkaido 080-0572, Japan.
J Equine Sci. 2023 Jun;34(2):47-49. doi: 10.1294/jes.34.47. Epub 2023 Jun 12.
To confirm the positive conversion of antibodies against erythrocyte antigens in horses, possible blood transfusion donor horses selected from draft horse populations were periodically monitored with an indirect antiglobulin (Coombs) test for approximately 3 years. In this study, 19 horses (16 females and 3 males) were investigated, and five mares showed alloantibodies during the monitoring period. Four mares were typically pregnant when positive conversion was detected, whereas no particular cause of conversion could be observed for one mare based on its clinical records. In the analyzed horses, most positive conversions were possibly due to pregnancy, as conversion occurred more often during this period than after parturition. Pregnancy is considered a key event for positive conversion. Additionally, in cases in which unknown causative sensitization is confirmed, continuous monitoring with a test to detect antibodies should be performed, even if the possible donor is selected and maintained.
为了确认马体内抗红细胞抗原抗体的阳转情况，从挽马种群中挑选出可能作为输血供体的马匹，采用间接抗球蛋白（库姆斯）试验进行了约3年的定期监测。在本研究中，对19匹马（16匹母马和3匹公马）进行了调查，其中5匹母马在监测期间出现了同种抗体。检测到阳转时，4匹母马处于典型的妊娠期，而根据一匹母马的临床记录，未观察到其阳转的特殊原因。在所分析的马匹中，大多数阳转可能是由于妊娠，因为在此期间发生阳转的情况比分娩后更频繁。妊娠被认为是阳转的关键事件。此外，在确认存在未知致敏原因的情况下，即使已经选定并维持了可能的供体，也应通过检测抗体的试验进行持续监测。
