Nazari Elham, Hasanzadeh Malihe, Rezvani Reza, Rejali Marzieh, Badpeyma Mohaddeseh, Delaram Zeinab, Mousavi-Seresht Leila, Akbari Mahdieh, Khazaei Majid, Ferns Gordon A, Avan Amir
Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Gynecology Oncology, Woman Health Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Infect Agent Cancer. 2023 Jul 6;18(1):42. doi: 10.1186/s13027-023-00517-8.
Cervical cancer is one of lethal cancers in women. As a global concern, identifying important factors of cancer is a useful strategy for prevention. Due to the role of diet/nutrition factors for cancer, the purpose of our study was to determine the impact of 150 nutrition/vitamin factors and 50 non-nutritional factor in cervical cancer and phase.
Population samples of 2088 healthy subjects and patients with cervical cancer were investigated. 200 factors such as vitamin E, B1, B6, fruits, HPV, and age were gathered. Deep learning, Decision tree, and correlation matrix were used for modeling and identifying important factors. SPSS 26, R4.0.3, and Rapid miner were utilized for implementation.
Our findings indicated that zinc, Iron, Niacin, Potassium, Phosphorous, and Cooper have a beneficial impact in reducing the risk of cervical cancer and progression of phase in Iranian women, as well as Salt, snacks and milk Were identified as high-risk food factors (P value < 0.05 and coefficient correlation > 0.6). Also, alcohol, and sex patient with two groups, HPV positive have an impact on cervical cancer incidence. Phosphorus and selenium in the Micronutrients category (R = 0.85, AUC = 0.993) and polyunsaturated fatty acid and salt in the Macronutrients category and other categories of nutrients were identified as the most effective factors in cervical cancer using deep learning (R = 0.93, AUC = 0.999).
A diet and rich nutrition can be helpful for the prevention of cervix cancer and may reduce the risk of disease. Additional research is necessary for different countries.
宫颈癌是女性致死性癌症之一。作为一个全球关注的问题,识别癌症的重要因素是预防的有效策略。由于饮食/营养因素在癌症中的作用,我们研究的目的是确定150种营养/维生素因素和50种非营养因素对宫颈癌及其分期的影响。
对2088名健康受试者和宫颈癌患者的人群样本进行了调查。收集了200个因素,如维生素E、B1、B6、水果、人乳头瘤病毒(HPV)和年龄。使用深度学习、决策树和相关矩阵进行建模并识别重要因素。利用SPSS 26、R4.0.3和Rapid miner进行实施。
我们的研究结果表明,锌、铁、烟酸、钾、磷和铜对降低伊朗女性患宫颈癌的风险和分期进展有有益影响,同时盐、零食和牛奶被确定为高风险食物因素(P值<0.05且相关系数>0.6)。此外,酒精以及两组中的性患者、HPV阳性对宫颈癌发病率有影响。在微量营养素类别中,磷和硒(R = 0.85,AUC = 0.993)以及宏量营养素类别和其他营养素类别中的多不饱和脂肪酸和盐被确定为使用深度学习在宫颈癌中最有效的因素(R = 0.93,AUC = 0.999)。
丰富的饮食和营养有助于预防宫颈癌,并可能降低患病风险。不同国家还需要进一步研究。