Meghalatha Thazhathuputhenpurayil Sadhasivan, Muninathan Natarajan
Central Research Laboratory, Meenakshi Medical College Hospital and Research Institute, Meenakshi Academy of Higher Education and Research, Kanchipuram Tamil Nadu, India - 631552.
Bioinformation. 2022 Sep 30;18(9):841-844. doi: 10.6026/97320630018841. eCollection 2022.
Female breast cancer is the leading malignancy surpassing lung cancer recently, and its incidence is continued to rise in many countries. The existing anticancer drugs have limitations like drug resistance and adverse effects leading to poor clinical outcomes. The natural compounds withaferin-A and propolis have been individually reported for their anticancer activity in preclinical models. However, the combined effect of these compounds has not been studied especially in breast cancer models. Therefore, it is of interest to evaluate the effect of Withaferin-A and propolis on Benz(a)pyrene-induced breast cancer. Wistar rats of female gender were treated with saline (normal control), Benz(a)pyrene (disease control), Benz(a)pyrene+ Withaferin-A or Propolis, Benz(a)pyrene+ Withaferin-A+ Propolis. At the end of the treatment, the plasma levels of carcino embryonic antigen (CEA) were measured. We observed a decrease in carcino embryonic antigen (CEA) levels in rats received withaferin-A and propolis combination rather than individual compounds indicating their beneficial role in breast cancer. Results of the present study show that propolis, when combined with withaferin A, exhibits better anti tumor activity than its individual effect in Benz (a) pyrene-induced mammary carcinogenesis.
女性乳腺癌是目前超过肺癌的主要恶性肿瘤，在许多国家其发病率持续上升。现有的抗癌药物存在诸如耐药性和不良反应等局限性，导致临床疗效不佳。天然化合物白屈菜红碱和蜂胶在临床前模型中已分别报道具有抗癌活性。然而，这些化合物的联合作用尚未进行研究，尤其是在乳腺癌模型中。因此，评估白屈菜红碱和蜂胶对苯并(a)芘诱导的乳腺癌的影响具有重要意义。将雌性Wistar大鼠分为生理盐水组（正常对照）、苯并(a)芘组（疾病对照）、苯并(a)芘+白屈菜红碱组或蜂胶组、苯并(a)芘+白屈菜红碱+蜂胶组进行处理。在处理结束时，测量血浆癌胚抗原(CEA)水平。我们观察到，接受白屈菜红碱和蜂胶联合治疗的大鼠癌胚抗原(CEA)水平下降，而非单独使用化合物，这表明它们在乳腺癌中具有有益作用。本研究结果表明，在苯并(a)芘诱导的乳腺癌发生过程中，蜂胶与白屈菜红碱联合使用时，其抗肿瘤活性优于单独使用。
