击中痛点：革兰氏阴性菌脂多糖作为疫苗靶点。
Hit 'em Where It Hurts: Gram-Negative Bacterial Lipopolysaccharide as a Vaccine Target.
机构信息
Center for Vaccine Development and Global Health, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
出版信息
Microbiol Mol Biol Rev. 2023 Sep 26;87(3):e0004522. doi: 10.1128/mmbr.00045-22. Epub 2023 Jul 11.
Abstract
Infections with antimicrobial-resistant (AMR) bacteria pose an increasing threat to the ability to perform surgical procedures, organ transplantation, and treat cancer among many other medical conditions. There are few new antimicrobials in the development pipeline. Vaccines against AMR Gram-negative bacteria may reduce the use of antimicrobials and prevent bacterial transmission. This review traces the origins of lipopolysaccharide (LPS)-based vaccines against Gram-negative bacteria, the role of O polysaccharides and LPS core regions as potential vaccine targets, the development of new vaccine technologies, and their application to vaccines in current development.
摘要
抗菌药物耐药（AMR）细菌感染对手术、器官移植以及癌症等多种医疗条件的治疗能力构成了日益严重的威胁。在研发管线中，新的抗菌药物寥寥无几。针对 AMR 革兰氏阴性菌的疫苗可能减少抗菌药物的使用并防止细菌传播。本综述追溯了针对革兰氏阴性菌的脂多糖（LPS）疫苗的起源，O 多糖和 LPS 核心区域作为潜在疫苗靶点的作用，新型疫苗技术的发展及其在当前开发疫苗中的应用。
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