手术时机对口腔癌患者生存率和生活质量的影响。
Impact of time-to-surgery on survival and quality of life in oral cancer.
作者信息
Tirelli Giancarlo, Boscolo-Rizzo Paolo, Pelloso Ludovica, Gardenal Nicoletta, Giudici Fabiola, Marcuzzo Alberto Vito, Tofanelli Margherita
机构信息
Department of Medical, Surgical and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.
Department of Medicine, Surgery and Health Sciences, Biostatistics Unit, University of Trieste, Trieste, Italy.
出版信息
Am J Otolaryngol. 2023 Nov-Dec;44(6):103984. doi: 10.1016/j.amjoto.2023.103984. Epub 2023 Jul 5.
PURPOSE
To investigate the association between time-to-surgery (TTS) and overall survival (OS), disease specific survival (DSS) and quality of life (QoL) in patients with oral squamous cell carcinoma (OSCC).
MATERIALS AND METHODS
116 patients with OSCC candidate to surgery were examined. TTS intervals starting from diagnosis (TTS-clinical-based) and from histological reports (TTS-biopsy-based) were calculated. The effects of TTS intervals and prognostic factors on 5-year OS and DSS were explored.
RESULTS
In our cohort advanced T-categories OSCCs with TTS < 30 days showed a trend to have higher DSS rate (p = 0.049). Patients with TTS-clinical-based < 30 days showed better postoperative QoL. Positive surgical margins, nodal involvement (pN+), DOI >10 mm, invasive surgery and extra-capsular extension in pN+ were found to be significantly associated with a poor OS and DSS.
CONCLUSIONS
TTS ≥ 30 days can adversely affect DSS, especially in the advanced T categories. Short TTS intervals resulted associated with a better postoperative QoL.
目的
探讨口腔鳞状细胞癌（OSCC）患者手术时间（TTS）与总生存期（OS）、疾病特异性生存期（DSS）及生活质量（QoL）之间的关联。
材料与方法
对116例拟行手术的OSCC患者进行检查。计算从诊断开始（基于临床的TTS）和从组织学报告开始（基于活检的TTS）的TTS间隔。探讨TTS间隔和预后因素对5年OS和DSS的影响。
结果
在我们的队列中，TTS<30天的晚期T分期OSCC患者显示出DSS率较高的趋势（p = 0.049）。基于临床的TTS<30天的患者术后QoL较好。手术切缘阳性、淋巴结受累（pN+）、DOI>10 mm、侵入性手术以及pN+中的包膜外扩展被发现与较差的OS和DSS显著相关。
结论
TTS≥30天会对DSS产生不利影响，尤其是在晚期T分期中。较短的TTS间隔与较好的术后QoL相关。
Zotero 插件