Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Sanders-Brown Center for Aging, Department of Neurology, University of Kentucky, Lexington, Kentucky, USA.
Alzheimers Dement. 2023 Dec;19(12):5755-5764. doi: 10.1002/alz.13382. Epub 2023 Jul 12.
People with Down syndrome (DS) often develop Alzheimer's disease (AD). Here, we asked whether ultrasensitive plasma immunoassays for a tau N-terminal fragment (NT1-tau) and Aβ isoforms predict cognitive impairment.
Plasma NT1-tau, Aβ , Aβ , and Aβ levels were measured in a longitudinal discovery cohort (N = 85 participants, 220 samples) and a cross-sectional validation cohort (N = 239). We developed linear models and predicted values in the validation cohort.
Discovery cohort linear mixed models for NT1-tau, Aβ , and Aβ were significant for age; there was no main effect of time. In cross-sectional models, NT1-tau increased and Aβ decreased with age. NT1-tau predicted cognitive and functional scores. The discovery cohort linear model for NT1-tau predicted levels in the validation cohort.
NT1-tau correlates with age and worse cognition in DS. Further validation of NT1-tau and other plasma biomarkers of AD neuropathology in DS cohorts is important for clinical utility.
唐氏综合征（DS）患者常发生阿尔茨海默病（AD）。在这里，我们探讨了超敏血浆免疫测定法检测 tau N 端片段（NT1-tau）和 Aβ 异构体是否可预测认知障碍。
对一个纵向发现队列（N=85 名参与者，220 个样本）和一个横断面验证队列（N=239）进行血浆 NT1-tau、Aβ、Aβ和 Aβ 水平的检测。我们建立了线性模型，并对验证队列进行了预测值分析。
发现队列中 NT1-tau、Aβ 和 Aβ 的线性混合模型均与年龄显著相关，时间无主要影响。在横断面模型中，NT1-tau 随年龄增长而增加，Aβ 随年龄增长而减少。NT1-tau 预测认知和功能评分。发现队列中 NT1-tau 的线性模型可以预测验证队列中的水平。
NT1-tau 与 DS 患者的年龄和认知障碍有关。进一步验证 DS 队列中 NT1-tau 和其他 AD 神经病理学的血浆生物标志物对于临床应用很重要。
