对 14 种抗生素的抗生素耐药谱：中国福建的一项多中心研究。
Antibiotic resistance profile of to 14 antibiotics: a multicenter study in Fujian, China.
机构信息
Department of Gastroenterology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China.
Department of Gastroenterology, Fujian Provincial Hospital, Fuzhou, Fujian, China.
出版信息
PeerJ. 2023 Jul 11;11:e15611. doi: 10.7717/peerj.15611. eCollection 2023.
BACKGROUND AND AIM
Efficacy of . ) eradication is related to the local antimicrobial resistance epidemiology. We aimed to investigate the antibiotic resistance of in Fujian, China.
METHODS
-infected patients in four centers were enrolled in the study from Oct 2019 to Jan 2022. The bacteria were isolated, cultured and identified from the biopsy of patients' gastric mucosa samples. Antimicrobial susceptibility testing was performed by a modified broth microdilution method for to seven guideline-recommended antibiotics and seven potential choices for eradication.
RESULTS
A total of 205 strains were isolated. The resistance rates of amoxicillin (AMX), amoxicillin and clavulanate potassium (AMC), cefixime (CFM), gentamicin (GEN), tetracycline (TET), doxycycline (DOX), azithromycin (AZM), clarithromycin (CLR), levofloxacin (LVFX), sparfloxacin (SPFX), metronidazole (MTZ), tinidazole (TID), rifampicin (RFP) and furazolidone (FZD) were 11.22%, 12.20%, 7.32%, 12.20%, 4.88%, 4.39%, 44.39%, 43.90%, 30.24%, 21.46%, 40.98%, 45.85%, 5.37% and 10.24%, respectively. The rates of pan-sensitivity, single, double, triple and multiple resistance for seven guideline-recommended antibiotics were 32.68%, 30.24%, 13.17%, 7.76%, and 14.15%, respectively. The main double-resistance patterns were CLR+MTZ (10/205, 5%) and CLR+LVFX (9/205, 4%). The main triple-resistance pattern was CLR+MTZ+ LVFX (15/205, 7%).
CONCLUSIONS
In Fujian, the prevalence of resistance to AZM, CLR, LVFX, SPFX, MTZ, and TID was high, whereas that to AMX, AMC, GEN, CFM, TET, DOX, RFP and FZD was relatively low. CFM and DOX are promising new choices for eradication.
背景与目的
根除的疗效与当地抗菌药物耐药情况有关。本研究旨在调查中国福建地区 对常见抗生素的耐药情况。
方法
2019 年 10 月至 2022 年 1 月，从四家中心的 感染患者胃黏膜活检样本中分离培养出细菌。采用肉汤微量稀释法对 株进行药敏试验，检测 株对七种指南推荐药物和七种潜在 根除药物的耐药性。
结果
共分离出 205 株 。阿莫西林（AMX）、阿莫西林克拉维酸钾（AMC）、头孢克肟（CFM）、庆大霉素（GEN）、四环素（TET）、多西环素（DOX）、阿奇霉素（AZM）、克拉霉素（CLR）、左氧氟沙星（LVFX）、司帕沙星（SPFX）、甲硝唑（MTZ）、替硝唑（TID）、利福平（RFP）和呋喃唑酮（FZD）的耐药率分别为 11.22%、12.20%、7.32%、12.20%、4.88%、4.39%、44.39%、43.90%、30.24%、21.46%、40.98%、45.85%、5.37%和 10.24%。七种指南推荐抗生素中，全敏感、单一耐药、双重耐药、三重耐药和多重耐药的比例分别为 32.68%、30.24%、13.17%、7.76%和 14.15%。主要的双重耐药模式为 CLR+MTZ（10/205，5%）和 CLR+LVFX（9/205，4%）。主要的三重耐药模式为 CLR+MTZ+LVFX（15/205，7%）。
结论
福建地区 对 AZM、CLR、LVFX、SPFX、MTZ 和 TID 的耐药率较高，而对 AMX、AMC、GEN、CFM、TET、DOX、RFP 和 FZD 的耐药率较低。CFM 和 DOX 可能是新的 根除药物选择。
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