间充质干细胞衍生的外泌体：一种修复心脏损伤的潜在治疗策略。

Mesenchymal stem cell-derived exosomes: a possible therapeutic strategy for repairing heart injuries.

作者信息

Zhu Zeshu, Zhu Ping, Fan Xiongwei, Mo Xiaoyang, Wu Xiushan

机构信息

The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China.

Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China.

出版信息

Front Cell Dev Biol. 2023 Jun 30;11:1093113. doi: 10.3389/fcell.2023.1093113. eCollection 2023.

Mesenchymal stem cells (MSCs) are one of the most potent therapeutic strategies for repairing cardiac injury. It has been shown in the latest studies that MSCs cannot survive in the heart for a long time. Consequently, the exosomes secreted by MSCs may dominate the repair of heart injury and promote the restoration of cardiac cells, vascular proliferation, immune regulation, etc. Based on the current research, the progress of the acting mechanism, application prospects and challenges of exosomes, including non-coding RNA, in repairing cardiac injuries are summarised in this article.