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1 型糖尿病患者从儿童期过渡到成人护理:来自图宾根过渡研究的 20 年经验。

Transition From Childhood to Adult Care in Patients with Type 1 Diabetes: 20 Years of Experience From the Tübinger Transition Study.

机构信息

Pediatric Diabetology, University Children's Hospital, Tübingen, Germany.

出版信息

Exp Clin Endocrinol Diabetes. 2023 Oct;131(10):532-538. doi: 10.1055/a-2132-9585. Epub 2023 Jul 19.

Abstract

AIMS

Transition from pediatric to adult care is difficult for patients with chronic diseases. In this study, factors associated with metabolic control in childhood-onset type 1 diabetes (T1D) after transfer to adult care were analyzed.

METHODS

Overall, 224 persons with T1D were contacted yearly from 1998 to 2019. They voluntarily answered a questionnaire about their current hemoglobin A1c (HbA1c) levels, diabetes-associated complications, kind of care, living conditions, and family situation. Then, mixed longitudinal-cross-sectional analyses were carried out.

RESULTS

Overall, 190 patients answered at least once (mean age: 26.6 years). Diabetes complications were mentioned by 10 patients (5 microalbuminuria, 5 retinopathy). Most patients (92.6%) were in diabetes-specific care during the first year after transfer, with a trend to leave diabetes-specific care during the observation period. Patients in diabetes-specific care displayed lower HbA1c levels (%/mmol/mol) (7.1/54 7.5/58). An important predictor for HbA1c after transfer was HbA1c during the year before transfer (r=0.67, p <0.001). Patients living alone showed no difference in HbA1c levels from those living with their parents. Married patients had lower HbA1c levels (7.0/53 7.3/56, p<0.05) than unmarried ones. Patients with children (15.8%) presented lower HbA1c levels (6.9/52 7.3/56, p <0.01) than those without.

CONCLUSIONS

Good metabolic results are favored in patients followed-up in specialized care, are married, and are parents. We recommend transfer to a diabetologist with experience in T1D at an individual age.

摘要

目的

对于患有慢性病的患者来说,从儿科过渡到成人护理是困难的。本研究分析了在转移到成人护理后,儿童期发病的 1 型糖尿病(T1D)患者代谢控制的相关因素。

方法

1998 年至 2019 年,每年共联系了 224 名 T1D 患者。他们自愿回答了一份关于他们当前糖化血红蛋白(HbA1c)水平、糖尿病相关并发症、护理类型、生活条件和家庭情况的问卷。然后,进行了混合纵向-横截面分析。

结果

总共 190 名患者至少回答了一次(平均年龄:26.6 岁)。10 名患者(5 名微量白蛋白尿,5 名视网膜病变)提到了糖尿病并发症。大多数患者(92.6%)在转移后的第一年接受糖尿病专科护理,在观察期间有离开糖尿病专科护理的趋势。接受糖尿病专科护理的患者 HbA1c 水平(%/mmol/mol)较低(7.1/54 7.5/58)。转移后 HbA1c 的一个重要预测因子是转移前一年的 HbA1c(r=0.67,p<0.001)。与与父母同住的患者相比,独居患者的 HbA1c 水平没有差异。已婚患者的 HbA1c 水平较低(7.0/53 7.3/56,p<0.05),而非已婚患者。有孩子的患者(15.8%)的 HbA1c 水平较低(6.9/52 7.3/56,p<0.01)。

结论

在接受专科护理、已婚和有子女的患者中,代谢结果较好。我们建议在个体化年龄时转至有 T1D 经验的糖尿病专家。

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