修剪结肠癌：TRIM21 介导的泛素化作为 Hippo 肿瘤抑制途径的激活剂。

TRIMming away colon cancer: TRIM21-mediated ubiquitination as an activator of the Hippo tumor suppressor pathway.

机构信息

Cancer Signaling and Epigenetics Program, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

出版信息

Cell Chem Biol. 2023 Jul 20;30(7):699-701. doi: 10.1016/j.chembiol.2023.06.023.

DOI:10.1016/j.chembiol.2023.06.023

Abstract

In this issue of Cell Chemical Biology, Liu et al. identify TRIM21-mediated ubiquitination of the Hippo pathway kinase MST2, promoting its dimerization and activation. The antidepressant Vilazodone was found to bind to TRIM21, enhancing its activity toward MST2, increasing Hippo activation, and reducing colorectal cancer metastasis.

摘要

在本期《细胞化学生物学》中，刘等人发现 TRIM21 介导 Hippo 通路激酶 MST2 的泛素化，促进其二聚化和激活。抗抑郁药维拉唑酮被发现与 TRIM21 结合，增强其对 MST2 的活性，增加 Hippo 的激活，减少结直肠癌转移。