Louisiana State University Health Sciences Center New Orleans, USA.
J Investig Med High Impact Case Rep. 2023 Jan-Dec;11:23247096231188251. doi: 10.1177/23247096231188251.
Morbidity and mortality associated with radiation-induced secondary malignancies (RISMs) have shifted treatment paradigms to minimize or eliminate radiation from treatment regimens. In this case, a 48-year-old woman was diagnosed with Hodgkin lymphoma (HL) and treated with radiotherapy in 2000. In 2018, she was diagnosed with ductal carcinoma in situ (DCIS) of the right breast and treated with a mastectomy. Soon after, she developed triple-negative invasive ductal carcinoma (IDC) in her reconstructed breast. The patient underwent a left lumpectomy, and pathology showed ER-/PR-/HER2+ IDC. This patient's multi-phenotypic DCIS and IDC presentation are suspected to be RISM due to her previous HL treatment regimen.
与放射诱导的继发性恶性肿瘤（RISMs）相关的发病率和死亡率已经改变了治疗模式，以尽量减少或消除治疗方案中的放射治疗。在这种情况下，一名 48 岁女性于 2000 年被诊断为霍奇金淋巴瘤（HL）并接受了放射治疗。2018 年，她被诊断出右侧乳腺导管原位癌（DCIS），并接受了乳房切除术。此后不久，她在重建的乳房中出现了三阴性浸润性导管癌（IDC）。患者接受了左乳房肿块切除术，病理显示 ER-/PR-/HER2+ IDC。由于她之前的 HL 治疗方案，该患者多表型 DCIS 和 IDC 的表现疑似为 RISM。
