视交叉上核移植仅在持续黑暗条件下起内源性振荡器的作用。

Suprachiasmatic nucleus transplants function as an endogenous oscillator only in constant darkness.

作者信息

Aguilar-Roblero R, García-Hernández F, Aguilar R, Arankowsky-Sandoval G, Drucker-Colín R

出版信息

Neurosci Lett. 1986 Aug 15;69(1):47-52. doi: 10.1016/0304-3940(86)90412-x.

Abstract

Rats which sustained lesions of the suprachiasmatic nucleus (SCN) were transplanted with fetal hypothalamic tissue which included the SCN. After the graft, animals were kept under a 12:12 light-dark (LD) cycle during 6 weeks at which time half the animals were placed in constant light (LL) and half in constant darkness (DD). The results showed that all grafted rats recovered the photoperiod under LD, but under constant conditions rats began to free-run only in DD. The results suggest that the grafted tissue functions as a self-sustained oscillator only in darkness.

摘要

对损毁了视交叉上核（SCN）的大鼠移植包含SCN的胎儿下丘脑组织。移植后，动物在12:12光暗（LD）周期下饲养6周，此时将一半动物置于持续光照（LL）下，另一半置于持续黑暗（DD）中。结果显示，所有移植大鼠在LD条件下恢复了光周期，但在恒定条件下，大鼠仅在DD中开始自由活动。结果表明，移植组织仅在黑暗中作为一个自我维持的振荡器发挥作用。