Department of Gynecology Endocrine and Reproductive Center, State Key Laboratory of Complex Severe and Rare Disease, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Front Endocrinol (Lausanne). 2023 Jul 10;14:1195256. doi: 10.3389/fendo.2023.1195256. eCollection 2023.
The aim of this study was to investigate whether maternal age had an effect on the birthweight of singletons delivered from frozen-thawed blastocyst transfer (FBT) cycles. A total of 1203 FBT cycles occurring between July 2011 and June 2021 at a single centre were retrospectively analysed. Based on the maternal age at FBT, the patients were divided into four groups: <30, 30-34, 35-37, and ≥38 years of age. Main outcomes measured included singleton birthweights, preterm births, large-for-gestational-age (LGA) and small-for-gestational-age (SGA) live births among the groups. There was no significant difference in birth weight among the four groups, while the highest birth weight was found in the <30 years group. The incidence of very preterm births and very low birth weights demonstrated an increasing trend with age; on the contrary, the incidence of preterm births, low birth weight (LBW), high birth weight and LGA and SGA live births gradually decreased with increasing age, but these differences were not statistically significant among groups (P>0.05, respectively). Although the proportion of females was lower than that of males, the difference was not statistically significant among the groups. After adjusting for possible confounders, maternal age was found to have no effect on adverse neonatal outcomes in the regression analyses (P>0.05). Birthweight in singleton births from FBT was not affected by maternal age.
本研究旨在探讨母体年龄是否会对冻融囊胚移植（FBT）周期中单胎的出生体重产生影响。回顾性分析了 2011 年 7 月至 2021 年 6 月在单一中心进行的 1203 例 FBT 周期。根据 FBT 时的母体年龄，将患者分为四组：<30 岁、30-34 岁、35-37 岁和≥38 岁。主要观察指标包括各组的单胎出生体重、早产、大于胎龄儿（LGA）和小于胎龄儿（SGA）的活产。四组间出生体重无显著差异，而<30 岁组出生体重最高。极早产和极低出生体重的发生率随年龄呈上升趋势；相反，早产、低出生体重（LBW）、高出生体重和 LGA 和 SGA 活产的发生率随年龄增加逐渐下降，但组间差异无统计学意义（分别为 P>0.05）。尽管女性比例低于男性，但组间差异无统计学意义。在调整可能的混杂因素后，回归分析发现母体年龄对不良新生儿结局无影响（P>0.05）。FBT 中单胎出生体重不受母体年龄影响。
