School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310007, China.
Biosensors (Basel). 2023 Jul 12;13(7):726. doi: 10.3390/bios13070726.
Precision medicine, particularly therapeutic drug monitoring (TDM), is essential for optimizing drug dosage and minimizing toxicity. However, current TDM methods have limitations, including the need for skilled operators, patient discomfort, and the inability to monitor dynamic drug level changes. In recent years, wearable sensors have emerged as a promising solution for drug monitoring. These sensors offer real-time and continuous measurement of drug concentrations in biofluids, enabling personalized medicine and reducing the risk of toxicity. This review provides an overview of drugs detectable by wearable sensors and explores biosensing technologies that can enable drug monitoring in the future. It presents a comparative analysis of multiple biosensing technologies and evaluates their strengths and limitations for integration into wearable detection systems. The promising capabilities of wearable sensors for real-time and continuous drug monitoring offer revolutionary advancements in diagnostic tools, supporting personalized medicine and optimal therapeutic effects. Wearable sensors are poised to become essential components of healthcare systems, catering to the diverse needs of patients and reducing healthcare costs.
精准医学，特别是治疗药物监测（TDM），对于优化药物剂量和最小化毒性至关重要。然而，目前的 TDM 方法存在局限性，包括需要熟练的操作人员、患者不适以及无法监测动态药物水平变化。近年来，可穿戴传感器已成为药物监测的一种有前途的解决方案。这些传感器可实时和连续测量生物流体中的药物浓度，实现个体化医疗并降低毒性风险。本综述概述了可通过可穿戴传感器检测的药物，并探讨了未来可实现药物监测的生物传感技术。它对多种生物传感技术进行了比较分析，并评估了它们集成到可穿戴检测系统中的优势和局限性。可穿戴传感器在实时和连续药物监测方面的有前途的能力为诊断工具带来了革命性的进步，支持个体化医疗和最佳治疗效果。可穿戴传感器有望成为医疗保健系统的重要组成部分，满足患者的多样化需求并降低医疗保健成本。
