饥饿失活的 MTOR 通过 ULK1-SH3PXD2A/TKS5-MMP14 通路在卵巢癌中触发细胞迁移。
Starvation-inactivated MTOR triggers cell migration via a ULK1-SH3PXD2A/TKS5-MMP14 pathway in ovarian carcinoma.
机构信息
Gynecologic Cancer Research Center, Chang Gung Memorial Hospital, Taoyuan City, Guishan District, Taiwan.
Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Linkou Medical Center And Chang Gung University, Taoyuan City, Guishan District, Taiwan.
出版信息
Autophagy. 2023 Dec;19(12):3151-3168. doi: 10.1080/15548627.2023.2239633. Epub 2023 Jul 28.
Abstract
AMPK
AMP-activated protein kinase; CHX: cycloheximide; RAD001: everolimus; HBSS: Hanks' balanced salt solution; LC-MS/MS: liquid chromatography-mass spectrometry/mass spectrometry; MMP14: matrix metallopeptidase 14; MTOR: mechanistic target of rapamycin kinase; MAPK: mitogen-activated protein kinase; RB1CC1/FIP200: RB1 inducible coiled-coil 1; PtdIns3P: phosphatidylinositol-3-phosphate; PX: phox homology; SH3: Src homology 3; SH3PXD2A/TKS5: SH3 and PX domains 2A; SH3PXD2A-[6A]: S112A S142A S146A S147A S175A S348A mutant; ULK1: unc-51 like autophagy activating kinase 1.
摘要
AMPK
AMP 激活的蛋白激酶；CHX：环己酰亚胺；RAD001：依维莫司；HBSS：Hanks 平衡盐溶液；LC-MS/MS：液相色谱-质谱/质谱；MMP14：基质金属蛋白酶 14；MTOR：雷帕霉素靶蛋白激酶；MAPK：丝裂原激活的蛋白激酶；RB1CC1/FIP200：RB1 诱导卷曲螺旋 1；PtdIns3P：磷脂酰肌醇-3-磷酸；PX：phox 同源；SH3：Src 同源 3；SH3PXD2A/TKS5：SH3 和 PX 结构域 2A；SH3PXD2A-[6A]：S112A S142A S146A S147A S175A S348A 突变体；ULK1：UNC-51 样自噬激活激酶 1。
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