Faculty of Medicine, Ovidius University of Constanta, 1 Universitatii Alley, 900470 Constanta, Romania.
Prof. Alexandru Obregia Psychiatry Hospital, 10 Berceni Str., 041914 Bucharest, Romania.
Medicina (Kaunas). 2023 Jul 3;59(7):1240. doi: 10.3390/medicina59071240.
: Calprotectin is a marker for intestinal inflammation. Recent research suggests a link between inflammation and depression. This study assessed the association between the levels of calprotectin in patients from South-Eastern Europe and the severity of depression, anxiety, and quality of life. : This cross-sectional study included 30 confirmed patients with Crohn's disease (CD) and ulcerative colitis (UC) who were assessed using clinical interviews for determining the severities of mental disorders (i.e., depression severity-PHQ-9, anxiety-GAD-7) and the quality of life (EQ-5D). Stool samples were collected from all participants for measuring their levels of calprotectin. : The level of calprotectin is correlated with PHQ-9 (ρ = 0.416, = 0.022) and EQ-5D (ρ = -0.304, = 0.033) but not with GAD 7 ρ = 0.059, = 0.379). Calprotectin levels in patients with mild, moderate, and moderately severe depression were significantly higher than in patients with minimal depression (198 µg/g vs. 66,9 µg/g, = 0.04). Calprotectin level was corelated with the following depressive symptoms: autolytic ideation (ρ = 0.557, = 0.001), fatigue (ρ = 0.514, = 0.002), slow movement (ρ = 0.490, = 0.003), and sleep disorders (ρ = 0.403, = 0.014). Calprotectin was an independent predictor of depression with an odds ratio of 1.01 (95%: 1.002-1.03, < 0.01). An ROC analysis showed that a level of calprotectin of 131 µg/g or higher has a sensitivity of 82%, a specificity of 61%, and an accuracy of 70% for predicting depression. In this study, no significant correlations were found between calprotectin level and anxiety. : Calprotectin levels are associated with the severity of depression, and checking for a calprotectin level of 131 µg/g or higher may be a potential accessible screening test for depression in patients with inflammatory bowel disease.
钙卫蛋白是肠道炎症的标志物。最近的研究表明炎症与抑郁之间存在关联。本研究评估了东南欧患者的钙卫蛋白水平与抑郁、焦虑和生活质量严重程度之间的关系。
这项横断面研究纳入了 30 名确诊的克罗恩病（CD）和溃疡性结肠炎（UC）患者，通过临床访谈评估精神障碍严重程度（即抑郁严重程度 PHQ-9、焦虑 GAD-7）和生活质量（EQ-5D）。从所有参与者中采集粪便样本以测量其钙卫蛋白水平。
钙卫蛋白水平与 PHQ-9 呈正相关（ρ=0.416， =0.022）和 EQ-5D 呈负相关（ρ=-0.304， =0.033），但与 GAD-7 无关（ρ=0.059， =0.379）。轻度、中度和中度重度抑郁患者的钙卫蛋白水平明显高于轻度抑郁患者（198μg/g 比 66.9μg/g， =0.04）。钙卫蛋白水平与以下抑郁症状相关：自伤意念（ρ=0.557， =0.001）、疲劳（ρ=0.514， =0.002）、动作缓慢（ρ=0.490， =0.003）和睡眠障碍（ρ=0.403， =0.014）。钙卫蛋白是抑郁的独立预测因子，优势比为 1.01（95%置信区间：1.002-1.03，<0.01）。ROC 分析显示，钙卫蛋白水平 131μg/g 或更高时，预测抑郁的敏感性为 82%，特异性为 61%，准确性为 70%。在本研究中，钙卫蛋白水平与焦虑之间未发现显著相关性。
钙卫蛋白水平与抑郁严重程度相关，检测钙卫蛋白水平 131μg/g 或更高可能是炎症性肠病患者抑郁的一种潜在可行的筛选试验。
