Cardoso Marcia, Ragan Izabela, Hartson Lindsay, Goodrich Raymond P
Terumo BCT, Inc., TERUMO Böood and Cell Technologies, Zaventem, 41 1930 Brussels, Belgium.
Infectious Disease Research Center, Department of Biomedical Science, Colorado State University, Fort Collins, CO 80521, USA.
Pathogens. 2023 Jul 5;12(7):911. doi: 10.3390/pathogens12070911.
Emerging infectious disease threats are becoming more frequent due to various social, political, and geographical pressures, including increased human-animal contact, global trade, transportation, and changing climate conditions. Since blood products for transfusion are derived from donated blood from the general population, emerging agents spread by blood contact or the transfusion of blood products are also a potential risk. Blood transfusions are essential in treating patients with anemia, blood loss, and other medical conditions. However, these lifesaving procedures can contribute to infectious disease transmission, particularly to vulnerable populations. New methods have been implemented on a global basis for the prevention of transfusion transmissions via plasma, platelets, and whole blood products. Implementing proactive pathogen reduction methods may reduce the likelihood of disease transmission via blood transfusions, even for newly emerging agents whose transmissibility and susceptibility are still being evaluated as they emerge. In this review, we consider the Mirasol PRT system for blood safety, which is based on a photochemical method involving riboflavin and UV light. We provide examples of how emerging threats, such as Ebola, SARS-CoV-2, hepatitis E, mpox and other agents, have been evaluated in real time regarding effectiveness of this method in reducing the likelihood of disease transmission via transfusions.
由于各种社会、政治和地理压力，包括人与动物接触增加、全球贸易、运输以及气候变化，新出现的传染病威胁正变得越来越频繁。由于用于输血的血液制品来自普通人群的献血，通过血液接触或输血传播的新病原体也是一种潜在风险。输血对于治疗贫血、失血和其他病症的患者至关重要。然而，这些挽救生命的程序可能会导致传染病传播，尤其是对弱势群体。全球已实施了新方法来预防通过血浆、血小板和全血制品进行的输血传播。实施积极的病原体灭活方法可能会降低通过输血传播疾病的可能性，即使对于那些其传播性和易感性在出现时尚在评估的新出现病原体也是如此。在本综述中，我们考虑用于血液安全的Mirasol病原体灭活系统，该系统基于一种涉及核黄素和紫外线的光化学方法。我们提供了一些实例，说明如何实时评估埃博拉、SARS-CoV-2、戊型肝炎、猴痘和其他病原体等新出现的威胁在降低通过输血传播疾病可能性方面该方法的有效性。
