结合代谢组学和光学相干断层扫描技术揭示ST段抬高型心肌梗死患者斑块侵蚀和斑块破裂的血浆代谢谱及生物标志物。
Combining metabolomics and OCT to reveal plasma metabolic profiling and biomarkers of plaque erosion and plaque rupture in STEMI patients.
作者信息
Luo Xing, Liu Minghao, Wang Shengfang, Chen Yuwu, Bao Xiaoyi, Lv Ying, Zhang Shan, Xu Biyi, Weng Xiuzhu, Bai Xiaoxuan, Zeng Ming, Zhao Chen, Li Ji, Jia Haibo, Yu Bo
机构信息
Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, PR China; Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin 150001, PR China.
Department of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, Harbin 150001, PR China; Key Laboratory of Myocardial Ischemia, Ministry of Education, Harbin Medical University, Harbin 150001, PR China.
出版信息
Int J Cardiol. 2023 Nov 1;390:131223. doi: 10.1016/j.ijcard.2023.131223. Epub 2023 Jul 28.
OBJECTIVE
Plaque erosion (PE) and plaque rupture (PR) are the main subtypes of ST-segment elevation myocardial infarction (STEMI), the differences of metabolic patterns between PE and PR remain largely unknown.
METHODS
132 STEMI patients were divided into training set (PR, n = 36; PE, n = 36) and test set (PR, n = 30; PE, n = 30), the plasma from patients were analyzed by liquid chromatography quadruple time-of-flight mass spectrometry.
RESULTS
We identified 56 and 28 differences in training and test set, respectively. Among these metabolites, it was found that docosahexaenoic acid (DHA), salicylic acid and proline were recognized in both tests. Receiver Operating Characteristic (ROC) analysis showed that the area under curve of docosahexaenoic acid (DHA) was 0.81 and 0.75 in training and test samples, respectively; proline was 0.67 and 0.74 in training and test samples, respectively; salicylic acid was 0.70 and 0.73 in training and test samples, respectively.
CONCLUSIONS
DHA, salicylic acid, and proline could be used as non-invasive biomarkers to differentiate PE and PR.
目的
斑块侵蚀（PE）和斑块破裂（PR）是ST段抬高型心肌梗死（STEMI）的主要亚型，PE和PR之间代谢模式的差异在很大程度上仍不清楚。
方法
将132例STEMI患者分为训练集（PR，n = 36；PE，n = 36）和测试集（PR，n = 30；PE，n = 30），采用液相色谱四极杆飞行时间质谱法分析患者血浆。
结果
我们在训练集和测试集分别鉴定出56个和28个差异。在这些代谢物中，发现二十二碳六烯酸（DHA）、水杨酸和脯氨酸在两项测试中均被识别。受试者工作特征（ROC）分析表明，训练样本和测试样本中二十二碳六烯酸（DHA）的曲线下面积分别为0.81和0.75；脯氨酸在训练样本和测试样本中分别为0.67和0.74；水杨酸在训练样本和测试样本中分别为0.70和0.73。
结论
DHA、水杨酸和脯氨酸可作为区分PE和PR的非侵入性生物标志物。
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