Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation, South China Agricultural University, Guangzhou, China.
National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China.
Arch Virol. 2023 Jul 31;168(8):216. doi: 10.1007/s00705-023-05841-3.
In this study, a new Salmonella phage, NX263, was isolated from sewage. This phage could lyse 90.57% (48/53) of the bacterial strains tested and showed good activity over a wide range of temperature (up to 60°C) and pH (5-10). Phylogenetic analysis showed that it should be classified as a member of the genus Skatevirus. The genome of phage NX263 is 46,574 bp in length with a GC content of 45.52%. It contains 89 open reading frames and two tRNA genes. No lysogeny, drug resistance, or virulence-associated genes were identified in the genome sequence, suggesting that this phage could potentially be used to treat Salmonella Pullorum infections.
在这项研究中，从污水中分离到一种新的沙门氏菌噬菌体 NX263。该噬菌体可以裂解 90.57%（48/53）的测试菌株，并且在很宽的温度（高达 60°C）和 pH 值（5-10）范围内都具有很好的活性。系统发育分析表明，它应归类为 Skatevirus 属的成员。噬菌体 NX263 的基因组长度为 46574bp，GC 含量为 45.52%。它包含 89 个开放阅读框和两个 tRNA 基因。基因组序列中未鉴定出溶原性、耐药性或毒力相关基因，表明该噬菌体可能有潜力用于治疗鸡白痢沙门氏菌感染。
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