影响两种新型芳基氟喹诺酮抗菌剂——二氟沙星（A-56619）和A-56620体外活性的因素。
Factors influencing the in vitro activity of two new aryl-fluoroquinolone antimicrobial agents, difloxacin (A-56619) and A-56620.
作者信息
Hirschhorn L, Neu H C
出版信息
Antimicrob Agents Chemother. 1986 Jul;30(1):143-6. doi: 10.1128/AAC.30.1.143.
Abstract
The in vitro activity of difloxacin (A-56619) and A-56620, two new aryl-difluoroquinolones, was decreased by magnesium at 9 mM and in assay at pH 5.5 or in urine. Resistance was seen with members of the family Enterobacteriaceae, Pseudomonas aeruginosa, and Staphylococcus aureus repeatedly exposed to subinhibitory concentrations of the compounds. The frequency of resistance was similar to that found for other new quinolones.
摘要
二氟沙星（A - 56619）和A - 56620这两种新型芳基二氟喹诺酮类药物的体外活性，在镁离子浓度为9 mM时、pH值为5.5的测定环境中或尿液中会降低。肠杆菌科细菌、铜绿假单胞菌和金黄色葡萄球菌反复接触亚抑菌浓度的这些化合物后会出现耐药性。耐药频率与其他新型喹诺酮类药物相似。
相似文献
1
Factors influencing the in vitro activity of two new aryl-fluoroquinolone antimicrobial agents, difloxacin (A-56619) and A-56620.
Antimicrob Agents Chemother. 1986 Jul;30(1):143-6. doi: 10.1128/AAC.30.1.143.
2
In vitro activity of two new aryl-fluoroquinolone antimicrobial agents, difloxacin (A-56619) and A-56620 compared to that of other antimicrobial agents.
Chemotherapy. 1987;33(1):28-39. doi: 10.1159/000238473.
3
In vitro evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones.
Antimicrob Agents Chemother. 1986 Feb;29(2):193-200. doi: 10.1128/AAC.29.2.193.
4
In vitro activity of A-56619 and A56620, two new aryl-fluoroquinolone antimicrobial agents.
Antimicrob Agents Chemother. 1986 Feb;29(2):355-8. doi: 10.1128/AAC.29.2.355.
5
Comparative antibacterial activities of temafloxacin hydrochloride (A-62254) and two reference fluoroquinolones.
Antimicrob Agents Chemother. 1987 Nov;31(11):1768-74. doi: 10.1128/AAC.31.11.1768.
6
In vitro activities of the quinolone antimicrobial agents A-56619 and A-56620.
Antimicrob Agents Chemother. 1985 Oct;28(4):514-20. doi: 10.1128/AAC.28.4.514.
7
In vitro evaluation of A-56619 and A-56620, two new quinolones.
Antimicrob Agents Chemother. 1986 Jan;29(1):40-3. doi: 10.1128/AAC.29.1.40.
8
In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones.
Antimicrob Agents Chemother. 1986 Feb;29(2):201-8. doi: 10.1128/AAC.29.2.201.
9
In vitro activity of temafloxacin, a new difluoro quinolone antimicrobial agent.
Eur J Clin Microbiol Infect Dis. 1988 Feb;7(1):58-63. doi: 10.1007/BF01962176.
10
Antimicrobial spectrum of Win 49375.
Antimicrob Agents Chemother. 1984 Jul;26(1):104-7. doi: 10.1128/AAC.26.1.104.
引用本文的文献
1
In vitro activities of two novel oxazolidinones (U100592 and U100766), a new fluoroquinolone (trovafloxacin), and dalfopristin-quinupristin against Staphylococcus aureus and Staphylococcus epidermidis.
Antimicrob Agents Chemother. 1996 Oct;40(10):2428-30. doi: 10.1128/AAC.40.10.2428.
2
In vitro activity of the new fluoroquinolone CP-99,219.
Antimicrob Agents Chemother. 1994 Nov;38(11):2615-22. doi: 10.1128/AAC.38.11.2615.
3
In vitro activity of four new quinolones in Mueller-Hinton broth and peritoneal dialysis fluid.
Eur J Clin Microbiol. 1987 Jun;6(3):324-6. doi: 10.1007/BF02017630.
4
Synergistic interactions of ciprofloxacin and extended-spectrum beta-lactams or aminoglycosides against multiply drug-resistant Pseudomonas maltophilia.
Antimicrob Agents Chemother. 1988 May;32(5):782-4. doi: 10.1128/AAC.32.5.782.
5
Comparative in vitro activity of a new fluorinated 4-quinolone, T-3262 (A-60969).
Antimicrob Agents Chemother. 1988 May;32(5):663-70. doi: 10.1128/AAC.32.5.663.
6
In vitro activity of temafloxacin, a new difluoro quinolone antimicrobial agent.
Eur J Clin Microbiol Infect Dis. 1988 Feb;7(1):58-63. doi: 10.1007/BF01962176.
7
Comparative in vitro activity of a new quinolone, AM-1091.
Antimicrob Agents Chemother. 1989 Jul;33(7):1036-41. doi: 10.1128/AAC.33.7.1036.
8
Cross-resistance of Pseudomonas aeruginosa to ciprofloxacin, extended-spectrum beta-lactams, and aminoglycosides and susceptibility to antibiotic combinations.
Antimicrob Agents Chemother. 1989 Aug;33(8):1368-72. doi: 10.1128/AAC.33.8.1368.
9
In vitro activity of S-ofloxacin.
Antimicrob Agents Chemother. 1989 Jul;33(7):1105-7. doi: 10.1128/AAC.33.7.1105.
10
In vitro activity of PD 117596-2, a broad-spectrum difluoroquinolone.
Eur J Clin Microbiol Infect Dis. 1989 Jul;8(7):644-50. doi: 10.1007/BF01968149.
本文引用的文献
1
Method of reliable determination of minimal lethal antibiotic concentrations.
Antimicrob Agents Chemother. 1980 Nov;18(5):699-708. doi: 10.1128/AAC.18.5.699.
2
In vitro and in vivo activity of DL-8280, a new oxazine derivative.
Antimicrob Agents Chemother. 1982 Oct;22(4):548-53. doi: 10.1128/AAC.22.4.548.
3
[The antibacterial activity in vitro of ofloxacin in comparison with other orally administered antimicrobial substances on ampicillin-resistant clinical isolates].
Arzneimittelforschung. 1984;34(11):1552-4.
4
Antibacterial activities of ciprofloxacin, norfloxacin, oxolinic acid, cinoxacin, and nalidixic acid.
Antimicrob Agents Chemother. 1984 May;25(5):633-7. doi: 10.1128/AAC.25.5.633.
5
Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria.
Antimicrob Agents Chemother. 1984 Mar;25(3):319-26. doi: 10.1128/AAC.25.3.319.
6
In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim.
Antimicrob Agents Chemother. 1983 Nov;24(5):754-63. doi: 10.1128/AAC.24.5.754.
7
Selection of multiple antibiotic resistance by quinolones, beta-lactams, and aminoglycosides with special reference to cross-resistance between unrelated drug classes.
Antimicrob Agents Chemother. 1984 Dec;26(6):797-801. doi: 10.1128/AAC.26.6.797.
8
In vitro activities of the quinolone antimicrobial agents A-56619 and A-56620.
Antimicrob Agents Chemother. 1985 Oct;28(4):514-20. doi: 10.1128/AAC.28.4.514.
9
In vitro evaluation of A-56619 and A-56620, two new quinolones.
Antimicrob Agents Chemother. 1986 Jan;29(1):40-3. doi: 10.1128/AAC.29.1.40.
10
Open, prospective study of the clinical efficacy of ciprofloxacin.
Antimicrob Agents Chemother. 1985 Jul;28(1):128-32. doi: 10.1128/AAC.28.1.128.
Zotero 插件