越南原发性浸润性乳腺癌女性不良预后的临床病理危险因素：一项回顾性队列研究
Clinicopathological Risk Factors of Unfavorable Outcomes in Vietnamese Women with Primary Invasive Breast Cancer: A Retrospective Cohort Study.
作者信息
Huynh Chau Giang, Huynh Nghiem Xuan, Truong Bich-Ha Thi, Thai Truc Thanh, Doan Phuong-Thao Thi
机构信息
Department of Pathology, Hung Vuong Hospital, Ho Chi Minh City, Vietnam.
Department of Obstetrics and Gynecology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam.
出版信息
Breast Cancer (Dove Med Press). 2023 Aug 1;15:551-561. doi: 10.2147/BCTT.S422289. eCollection 2023.
BACKGROUND
The rate of unfavorable outcomes, such as recurrence and death, in women with invasive breast cancer varies widely across countries and populations. Identifying those with high-risk profiles is critical so that early detection, prediction, and intervention can be made to improve their survival rate. Therefore, our study evaluated the rate of unfavorable outcomes and its association with clinicopathological characteristics in Vietnamese women with primary invasive breast cancer.
METHODS
A retrospective open cohort study was conducted on Vietnamese women with invasive breast cancer who underwent a mastectomy and were regularly followed up by the hospitals. Kaplan-Meier method was used to estimate the rate of unfavorable outcomes to take into account the follow-up time of each patient. Univariate and multiple Cox regression analyses were conducted to examine the associations between unfavorable outcomes and clinicopathological characteristics.
RESULTS
Among 204 women included in the data analysis, the mean age was 54.4 ± 10.9 years. The majority of patients were diagnosed with early-stage (76.5%) or locally advanced (22.5%) breast cancer. The 5-year rate of unfavorable outcomes was 12.8%, and the 8-year rate was 31.7%. Patients with advanced stages had a higher risk of unfavorable outcomes compared to those with early stages (IA, IIA, T2N1). Patients with lymph node metastases and those with triple-negative molecular classification had significantly higher rates of unfavorable outcomes.
CONCLUSION
Although Vietnamese women with breast cancer have a relatively low rate of unfavorable outcomes compared to other countries, findings from this study emphasize the importance of early detection and underscore the need for targeted interventions for patients with advanced stages, lymph node metastases, and triple-negative breast cancer to optimize their treatment, outcomes, and overall prognosis.
背景
浸润性乳腺癌女性患者出现复发和死亡等不良结局的发生率在不同国家和人群中差异很大。识别出具有高风险特征的患者至关重要，以便能够进行早期检测、预测和干预，从而提高其生存率。因此，我们的研究评估了越南原发性浸润性乳腺癌女性患者的不良结局发生率及其与临床病理特征的关联。
方法
对接受乳房切除术并在医院定期随访的越南浸润性乳腺癌女性患者进行了一项回顾性开放队列研究。采用Kaplan-Meier方法估计不良结局发生率，以考虑每位患者的随访时间。进行单因素和多因素Cox回归分析，以检验不良结局与临床病理特征之间的关联。
结果
纳入数据分析的204名女性患者的平均年龄为54.4±10.9岁。大多数患者被诊断为早期（76.5%）或局部晚期（22.5%）乳腺癌。不良结局的5年发生率为12.8%，8年发生率为31.7%。与早期（IA、IIA、T2N1）患者相比，晚期患者出现不良结局的风险更高。有淋巴结转移的患者和三阴性分子分类的患者不良结局发生率显著更高。
结论
尽管与其他国家相比，越南乳腺癌女性患者的不良结局发生率相对较低，但本研究结果强调了早期检测的重要性，并强调需要对晚期、有淋巴结转移和三阴性乳腺癌患者进行有针对性的干预，以优化其治疗、结局和总体预后。
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