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体外膜肺氧合患者的姑息治疗利用:一项观察性研究。

Palliative Care Utilization in Patients Requiring Extracorporeal Membrane Oxygenation: An Observational Study.

机构信息

From the Cicely Saunders Institute of Palliative Care, Policy, and Rehabilitation, King's College London, London, United Kingdom.

University of Wollongong, Wollongong, New South Wales, Australia.

出版信息

ASAIO J. 2023 Nov 1;69(11):1009-1015. doi: 10.1097/MAT.0000000000002021. Epub 2023 Aug 6.

Abstract

Palliative care (PC) is a model of care centered around improving the quality of life for individuals with life-limiting illnesses. Few studies have examined its impact in patients on extracorporeal membrane oxygenation (ECMO). We aimed to describe demographics, clinical characteristics, and complications associated with PC consultation in adult patients requiring ECMO support. We analyzed data from an ECMO registry, including patients aged 18 years and older who have received either venoarterial (VA)- or venovenous (VV)-ECMO support between July 2016 and September 2021. We used analysis of variance and Fisher exact tests to identify factors associated with PC consultation. Of 256, 177 patients (69.1%) received VA-ECMO support and 79 (30.9%) received VV-ECMO support. Overall, 115 patients (44.9%) received PC consultation while on ECMO. Patients receiving PC consultation were more likely to be non-white (47% vs. 53%, p = 0.016), have an attending physician from a medical versus surgical specialty (65.3% vs. 39.6%), have VV-ECMO (77.2% vs. 30.5%, p < 0.001), and have longer ECMO duration (6.2 vs. 23.0, p < 0.001). Patients were seen by the PC team on an average of 7.6 times (range, 1-35), with those who died having significantly more visits (11.2 vs. 5.6, p < 0.001) despite the shorter hospital stay. The average time from cannulation to the first PC visit was 5.3 ± 5 days. Congestive heart failure in VA-ECMO, coronavirus disease 2019 infection in VV-ECMO, and non-white race and longer ECMO duration for all patients were associated with PC consultation. We found that despite the benefits of PC, it is underused in this population.

摘要

缓和医疗(PC)是一种以改善生命有限疾病患者生活质量为中心的护理模式。很少有研究探讨其在接受体外膜肺氧合(ECMO)支持的患者中的影响。我们旨在描述需要 ECMO 支持的成年患者接受 PC 咨询的人口统计学、临床特征和并发症。我们分析了 ECMO 注册中心的数据,包括 2016 年 7 月至 2021 年 9 月期间接受静脉-动脉(VA)-或静脉-静脉(VV)-ECMO 支持的年龄在 18 岁及以上的患者。我们使用方差分析和 Fisher 精确检验来确定与 PC 咨询相关的因素。在 256 名患者中,177 名(69.1%)接受 VA-ECMO 支持,79 名(30.9%)接受 VV-ECMO 支持。总的来说,115 名(44.9%)患者在接受 ECMO 治疗时接受了 PC 咨询。接受 PC 咨询的患者更有可能是非裔美国人(47% vs. 53%,p=0.016)、主治医生来自医学专业而非外科专业(65.3% vs. 39.6%)、接受 VV-ECMO(77.2% vs. 30.5%,p<0.001)以及 ECMO 持续时间更长(6.2 vs. 23.0,p<0.001)。PC 团队平均对患者进行了 7.6 次(范围为 1-35 次)就诊,尽管住院时间更短,但死亡患者的就诊次数明显更多(11.2 次 vs. 5.6 次,p<0.001)。从置管到第一次 PC 就诊的平均时间为 5.3±5 天。VA-ECMO 中的充血性心力衰竭、VV-ECMO 中的 2019 年冠状病毒病感染以及所有患者中的非裔美国人种族和更长的 ECMO 持续时间与 PC 咨询相关。我们发现,尽管 PC 有其益处,但在该人群中仍未得到充分利用。

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