Zhou Nengneng, Zhao Fangli, Wang Lei, Gao Xiang, Zhao Xiaowei, Zhang Man
Key Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241000, China.
Org Lett. 2023 Aug 18;25(32):6072-6076. doi: 10.1021/acs.orglett.3c02323. Epub 2023 Aug 7.
A novel and efficient strategy for the synthesis of a series of structurally interesting benzazepine derivatives via an -heterocyclic carbene-catalyzed regioselective intramolecular radical cyclization has been developed. This protocol features good regioselectivity, good functional-group compatibility, and wide substrate scope, providing a transition-metal- and oxidant-free pathway to access the seven-membered rings under mild reaction conditions. Additionally, further transformation of benzazepines and a large-scale experiment were also conducted.
已开发出一种新颖且高效的策略，通过氮杂环卡宾催化的区域选择性分子内自由基环化反应合成一系列结构有趣的苯并氮杂卓衍生物。该方法具有良好的区域选择性、良好的官能团兼容性和广泛的底物范围，在温和的反应条件下提供了一条无过渡金属和无氧化剂的途径来构建七元环。此外，还进行了苯并氮杂卓的进一步转化和大规模实验。
