价值动态会影响决策过程中的选择准备。
Value dynamics affect choice preparation during decision-making.
机构信息
Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA, USA.
Department of Psychology, University of California at Berkeley, Berkeley, CA, USA.
出版信息
Nat Neurosci. 2023 Sep;26(9):1575-1583. doi: 10.1038/s41593-023-01407-3. Epub 2023 Aug 10.
During decision-making, neurons in the orbitofrontal cortex (OFC) sequentially represent the value of each option in turn, but it is unclear how these dynamics are translated into a choice response. One brain region that may be implicated in this process is the anterior cingulate cortex (ACC), which strongly connects with OFC and contains many neurons that encode the choice response. We investigated how OFC value signals interacted with ACC neurons encoding the choice response by performing simultaneous high-channel count recordings from the two areas in nonhuman primates. ACC neurons encoding the choice response steadily increased their firing rate throughout the decision-making process, peaking shortly before the time of the choice response. Furthermore, the value dynamics in OFC affected ACC ramping-when OFC represented the more valuable option, ACC ramping accelerated. Because OFC tended to represent the more valuable option more frequently and for a longer duration, this interaction could explain how ACC selects the more valuable response.
在决策过程中，眶额皮质（OFC）中的神经元依次依次表示每个选项的价值，但尚不清楚这些动态如何转化为选择反应。在这个过程中可能涉及的一个脑区是前扣带皮层（ACC），它与 OFC 强烈连接，并且包含许多编码选择反应的神经元。我们通过在非人类灵长类动物中同时进行来自两个区域的高通道计数记录，研究了 OFC 中的价值信号如何与编码选择反应的 ACC 神经元相互作用。编码选择反应的 ACC 神经元在整个决策过程中稳定地增加其发射率，在选择反应之前不久达到峰值。此外，OFC 中的价值动态影响了 ACC 的斜率——当 OFC 表示更有价值的选项时，ACC 的斜率会加速。由于 OFC 往往更频繁地表示更有价值的选项，并且持续时间更长，这种相互作用可以解释 ACC 如何选择更有价值的反应。
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