胞内信号分子在泥炭腐殖酸激活巨噬细胞中的作用。
The Role of Intracellular Signaling Molecules in Macrophage Activation by Peat Humic Acids.
机构信息
E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Siberian State Medical University, Ministry of Health of the Russian Federation, Tomsk, Russia.
出版信息
Bull Exp Biol Med. 2023 Jul;175(3):353-357. doi: 10.1007/s10517-023-05866-3. Epub 2023 Aug 10.
Humic acids isolated by sodium pyrophosphate extraction from various types of peat activate macrophages in the classical proinflammatory pathway and stimulate nitric oxide production by these cells. This effect is mediated by activation of intracellular signaling pathways involving MAPK p38, PI3K, MEK 1/2 kinase, cAMP, and NF-κB via TLR-2 and TLR-4 receptors.
焦磷酸钠从各种类型的泥炭中提取的腐殖酸通过经典的促炎途径激活巨噬细胞，并刺激这些细胞产生一氧化氮。这种作用是通过细胞内信号通路的激活介导的，涉及 MAPK p38、PI3K、MEK 1/2 激酶、cAMP 和 NF-κB，通过 TLR-2 和 TLR-4 受体。
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