适应 性 深 脑 刺 激 用 于 帕 金 森 病 的 睡 眠 阶 段 靶 向。
Adaptive Deep Brain Stimulation for sleep stage targeting in Parkinson's disease.
机构信息
Department of Bioengineering, University of California, San Francisco, UCSF Byers Hall Box 2520, 1700 Fourth St Ste 203, San Francisco, CA, 94143, United States.
Department of Neurology, University of California, San Francisco, Eighth Floor, 400 Parnassus Ave, San Francisco, CA, 94143, United States.
出版信息
Brain Stimul. 2023 Sep-Oct;16(5):1292-1296. doi: 10.1016/j.brs.2023.08.006. Epub 2023 Aug 9.
BACKGROUND
Sleep dysfunction is disabling in people with Parkinson's disease and is linked to worse motor and non-motor outcomes. Sleep-specific adaptive Deep Brain Stimulation has the potential to target pathophysiologies of sleep.
OBJECTIVE
Develop an adaptive Deep Brain Stimulation algorithm that modulates stimulation parameters in response to intracranially classified sleep stages.
METHODS
We performed at-home, multi-night intracranial electrocorticography and polysomnogram recordings to train personalized linear classifiers for discriminating the N3 NREM sleep stage. Classifiers were embedded into investigational Deep Brain Stimulators for N3 specific adaptive DBS.
RESULTS
We report high specificity of embedded, autonomous, intracranial electrocorticography N3 sleep stage classification across two participants and provide proof-of-principle of successful sleep stage specific adaptive Deep Brain Stimulation.
CONCLUSION
Multi-night cortico-basal recordings and sleep specific adaptive Deep Brain Stimulation provide an experimental framework to investigate sleep pathophysiology and mechanistic interactions with stimulation, towards the development of therapeutic neurostimulation paradigms directly targeting sleep dysfunction.
背景
睡眠功能障碍在帕金森病患者中很常见，且与更差的运动和非运动结果有关。针对睡眠的特定适应性脑深部刺激具有针对睡眠病理生理学的潜力。
目的
开发一种适应性脑深部刺激算法，该算法可根据颅内分类的睡眠阶段来调节刺激参数。
方法
我们进行了多晚的颅内脑电图和多导睡眠图记录，以训练用于区分 N3 非快速眼动睡眠阶段的个性化线性分类器。分类器被嵌入到研究用的脑深部刺激器中，以实现 N3 特定的适应性脑深部刺激。
结果
我们报告了两名参与者的嵌入式、自主的颅内脑电图 N3 睡眠阶段分类具有很高的特异性，并提供了成功的睡眠阶段特定适应性脑深部刺激的原理证明。
结论
多晚的皮质基底记录和睡眠特定适应性脑深部刺激提供了一个实验框架，用于研究睡眠病理生理学以及与刺激的机制相互作用，从而开发直接针对睡眠功能障碍的治疗性神经刺激范式。
Zotero 插件