Antibacterial mechanism of lignin and lignin-based antimicrobial materials in different fields.

The control of microbial infection transmission often relies on the utilization of synthetic and metal-based antimicrobial agents. However, their non-biodegradability and inadequate disposal practices lead to significant environmental contamination. To address this concern, the quest for natural alternatives has gained paramount importance. Lignin, a widely available renewable aromatic compound, emerges as a promising candidate owing to its inherent phenolic moiety, which lends itself well to acting as a natural antimicrobial agent either independently or in combination with other agents. This article provides a comprehensive account of the structure and primary classes of lignin. Additionally, it elucidates the antimicrobial mechanism of lignin, the factors influencing its efficacy, and the methods employed for its detection. Moreover, it describes the progress made in developing the antimicrobial capacity of lignin in different areas. In conclusion, this paper not only outlines the current state of research on the antimicrobial function of lignin, but also identifies challenges and future possibilities for enhancing its antimicrobial properties. This work holds great significance in the ongoing endeavor to contribute to high-impact research on natural alternatives for controlling infections and fostering environmentally conscious practices.