核内无膜隔间：分隔还是连接的相？
Membrane-less compartments in the nucleus: Separated or connected phases?
机构信息
Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.
出版信息
Curr Opin Cell Biol. 2023 Oct;84:102215. doi: 10.1016/j.ceb.2023.102215. Epub 2023 Aug 11.
In recent years, it has become increasingly clear that many nuclear membrane-less compartments have liquid-like properties and may form through the physicochemical process of phase separation. In this review, we will first discuss how various nuclear compartments, such as the genome, transcription compartments, and nuclear bodies are formed through phase separation. Then, we propose that inter-compartmental communications can also be prevalent and may be mediated by inter-compartmental diffusion of macromolecules, fusion among different compartments, and transient or stable contacts among nuclear compartments. Understanding how nuclear compartments communicate with each other represents an exciting new area of research and may reveal important insights about cellular functions and uncover previously under-appreciated disease mechanisms.
近年来，越来越明显的是，许多核无膜隔间具有类似液体的性质，并且可能通过相分离的物理化学过程形成。在这篇综述中，我们将首先讨论基因组、转录隔间和核体等各种核隔间如何通过相分离形成。然后，我们提出隔间之间的交流也可能很普遍，并且可能通过大分子隔间之间的扩散、不同隔间之间的融合以及核隔间之间的瞬时或稳定接触来介导。了解核隔间如何相互通信是一个令人兴奋的新研究领域，可能揭示关于细胞功能的重要见解，并揭示以前未被充分认识的疾病机制。
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