孕妇血清和脐血中的降钙素原水平作为早发型新生儿败血症诊断标志物
Procalcitonin levels in maternal serum and cord blood as marker for diagnosis of early onset neonatal sepsis.
作者信息
Yadav Puja, Agarwal Kavita, Rani Anita, Dewan Rupali, Chellani Harish
机构信息
Deptt. Of Obs. & Gynae, VMMC & Safdarjung Hospital, Delhi, India.
Deptt. of Biochemistry, VMMC & Safdarjung Hospital, Delhi, India.
出版信息
Eur J Obstet Gynecol Reprod Biol X. 2023 Jul 30;19:100221. doi: 10.1016/j.eurox.2023.100221. eCollection 2023 Sep.
OBJECTIVES
To assess the diagnostic accuracy of Procalcitonin in maternal serum and umbilical cord blood samples to predict Early onset neonatal sepsis (EONS).
STUDY DESIGN
It was a Prospective analytical cohort study. Pregnant women ≥ 34 weeks gestation in active labour, with risk factors for EONS were included in the study. Maternal blood samples at recruitment and umbilical cord blood samples after delivery were taken for Total leucocyte count (TLC), high sensitivity C-Reactive Protein (hs-CRP) and Procalcitonin. Newborns were classified into non-infected, suspected and proven infection. Sensitivity, specificity and diagnostic accuracy of maternal and cord blood procalcitonin, TLC and hs-CRP were calculated.
RESULTS
A total of 200 women were recruited. Maternal procalcitonin had a superior diagnostic accuracy of 99% compared to maternal TLC and maternal hs-CRP. Also, cord blood procalcitonin had a diagnostic accuracy of 95%.
CONCLUSION
Procalcitonin in both maternal as well as cord blood is a promising biomarker to detect EONS with high diagnostic accuracy.
目的
评估母体血清和脐带血样本中降钙素原预测早发型新生儿败血症（EONS）的诊断准确性。
研究设计
这是一项前瞻性分析队列研究。纳入妊娠≥34周且处于活跃分娩期、具有EONS危险因素的孕妇。在招募时采集母体血样，分娩后采集脐带血样，检测全白细胞计数（TLC）、高敏C反应蛋白（hs-CRP）和降钙素原。将新生儿分为未感染、疑似感染和确诊感染。计算母体和脐带血降钙素原、TLC和hs-CRP的敏感性、特异性和诊断准确性。
结果
共招募了200名女性。与母体TLC和母体hs-CRP相比，母体降钙素原具有更高的诊断准确性，为99%。此外，脐带血降钙素原的诊断准确性为95%。
结论
母体和脐带血中的降钙素原都是检测EONS的有前景的生物标志物，具有较高的诊断准确性。
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