Department of Small Animal Medicine & Surgery, University of Georgia, College of Veterinary Medicine, Athens, GA, USA.
Department of Population Health, University of Georgia, College of Veterinary Medicine, Athens, GA, USA.
J Feline Med Surg. 2023 Aug;25(8):1098612X231188770. doi: 10.1177/1098612X231188770.
Situational increases in blood pressure (BP) frequently confound the accurate diagnosis of pathological systemic hypertension in cats. The objective of this study was to investigate the effect of gabapentin on direct, ambulatory systolic arterial BP (SBP) in cats in at-home and in-clinic environments.
Six adult purpose-bred cats with surgically implanted femoral artery telemetric BP-sensing catheters were administered 100 mg of gabapentin or a placebo orally in two randomized, masked, crossover study phases. In the first, direct BP was measured continuously in undisturbed cats for 24 h before (at-home baseline) and 4 h after administration of study drug. The mean SBP after administration of the drug was compared between treatments. In the second study period, cats were administered gabapentin or placebo 90 mins before transport to a clinic, where direct BP was measured continuously during a simulated veterinary visit that included an indirect BP measurement session. Changes in mean direct SBP relative to the 24-h at-home pre-treatment period were calculated for each of one waiting room and two examination-room periods, and compared between treatments. Concurrent in-clinic direct and indirect SBP measurements were compared within-cat. Data were compared using linear mixed models.
Direct SBP data from one cat were excluded due to implant failure. There were no differences in at-home or in-clinic SBP between treatment groups, with large inter-individual variability. Cats in both treatment groups experienced in-clinic increases in direct SBP relative to at-home baseline (range 11-50 and 10-52 mmHg in placebo- and gabapentin-treated cats, respectively). Across all visits, direct SBP was 15.6 mmHg higher than indirect SBP ( <0.001). No effects of treatment on difference between direct and indirect SBP were identified.
Significant effects of gabapentin on direct SBP were not identified, though a type II error is possible. Situational increases cannot be excluded in gabapentin-treated cats with high SBP.
血压（BP）的情况性升高常使猫科动物病理性系统性高血压的准确诊断复杂化。本研究的目的是探讨加巴喷丁对在家中和诊所环境中猫科动物直接、动态收缩动脉 BP（SBP）的影响。
6 只成年、经专门饲养、植入股动脉遥测 BP 传感器导管的猫，在两个随机、双盲、交叉研究阶段中分别口服 100mg 加巴喷丁或安慰剂。在第一个阶段，在药物给药前（在家中基线）和给药后 4 小时，连续、不干扰地测量未受干扰的猫的直接 BP，比较两种治疗方法后药物给药后的平均 SBP。在第二个研究期间，猫在运送到诊所前 90 分钟给予加巴喷丁或安慰剂，在模拟兽医就诊期间连续测量直接 BP，其中包括间接 BP 测量。计算每个等候室和两个检查室期间相对于 24 小时在家治疗前周期的平均直接 SBP 的变化，并比较两种治疗方法。比较了同一猫的诊所内直接和间接 SBP 测量值。使用线性混合模型比较数据。
由于植入物失败，一只猫的直接 SBP 数据被排除在外。在家中或诊所内 SBP 在治疗组之间没有差异，个体间差异很大。与在家中基线相比，两组猫在诊所内均出现直接 SBP 升高（安慰剂和加巴喷丁治疗猫分别为 11-50mmHg 和 10-52mmHg）。在所有就诊中，直接 SBP 比间接 SBP 高 15.6mmHg（<0.001）。未发现治疗对直接和间接 SBP 之间差异的影响。
未发现加巴喷丁对直接 SBP 有显著影响，但可能存在 II 型错误。不能排除在 SBP 高的加巴喷丁治疗猫中出现情况性升高。
