Szeimies R-M, Stege H
Klinikum Vest, Dorstener Str. 151, 45657, Recklinghausen, Deutschland.
Klinikum Lippe, Detmold, Deutschland.
Dermatologie (Heidelb). 2023 Sep;74(9):663-669. doi: 10.1007/s00105-023-05208-4. Epub 2023 Aug 18.
Actinic keratoses (AKs) are common precancerous skin lesions that primarily affect older adults due to cumulative sun exposure. Given the increased vulnerability of older adults to developing AKs, appropriate therapeutic strategies are crucial to prevent their progression to invasive squamous cell carcinoma. This comprehensive review aims to explore the various treatment modalities available for AKs in the elderly population, focusing on their efficacy, safety, and suitability for this specific age group. The article discusses topical treatments, cryotherapy, photodynamic therapy, chemical peels, and surgical interventions, providing a detailed analysis of their mechanisms of action, benefits, limitations, and considerations in geriatric patients. Furthermore, the importance of individualized treatment plans, considering factors such as comorbidities, medication interactions, and patient preferences, are highlighted.
光化性角化病（AKs）是常见的癌前皮肤病变，主要因长期累积日晒影响老年人。鉴于老年人患AKs的易感性增加，适当的治疗策略对于预防其进展为浸润性鳞状细胞癌至关重要。这篇综述旨在探讨老年人群中AKs可用的各种治疗方式，重点关注其疗效、安全性以及对该特定年龄组的适用性。文章讨论了局部治疗、冷冻疗法、光动力疗法、化学剥脱术和手术干预，详细分析了它们的作用机制、益处、局限性以及老年患者的注意事项。此外，强调了制定个体化治疗方案的重要性，需考虑合并症、药物相互作用和患者偏好等因素。
