Trivedi Vijay Laxmi, Soni Ruchi, Dhyani Praveen, Sati Priyanka, Tejada Silvia, Sureda Antoni, Setzer William N, Faizal Abdull Razis Ahmad, Modu Babagana, Butnariu Monica, Sharifi-Rad Javad
High Altitude Plant Physiology Research Centre (HAPPRC), HNB. Garhwal University (A Central University), Srinagar Garhwal, Uttarakhand, India.
Regional Centre for Organic and Natural Farming, Ghaziabad, Uttar Pradesh, India.
Front Pharmacol. 2023 Aug 3;14:1187181. doi: 10.3389/fphar.2023.1187181. eCollection 2023.
With the advent of highly effective plant-based medications with few or no side effects, the use of phytomedicines against complex diseases such as cancer is becoming more widespread. The broadly recognized pentacyclic triterpenes known as boswellic acids (BAs) are derived from the oleogum resin, or frankincense, extracted from the plant species of the genus . The frankincense mixture contains various BA types, each having a different potential and helping treat certain cancers. This review focuses on details regarding the traits of the BAs, their roles as anti-cancer agents, the mechanism underlying their activities, and the function of their semi-synthetic derivatives in managing and treating certain cancers. The review also explores the biological sources of BAs, how they are conserved, and how biotechnology might help preserve and improve BA production. The review concludes that the BAs and their semi-synthetic derivatives are effective against a broad spectrum of cancer cell lines. The detailed information in the review can be helpful for researchers to gain more information about BAs and BA-based medications for efficient and cost-effective cancer treatments.
随着副作用很少或没有副作用的高效植物性药物的出现,使用植物药治疗癌症等复杂疾病正变得越来越普遍。被广泛认可的五环三萜类化合物,即乳香酸(BAs),来源于从植物属的植物中提取的油胶树脂,即乳香。乳香混合物包含各种类型的乳香酸,每种都有不同的潜力并有助于治疗某些癌症。本综述重点关注乳香酸的特性细节、它们作为抗癌剂的作用、其活性的潜在机制,以及它们的半合成衍生物在管理和治疗某些癌症中的功能。该综述还探讨了乳香酸的生物来源、它们是如何保存的,以及生物技术如何有助于保存和提高乳香酸的产量。该综述得出结论,乳香酸及其半合成衍生物对广泛的癌细胞系有效。综述中的详细信息有助于研究人员获取更多关于乳香酸和基于乳香酸的药物的信息,以实现高效且经济有效的癌症治疗。