载脂蛋白B编辑酶催化多肽样3（APOBEC3）诱导的突变在猴痘病毒差异进化中的作用。

Li Xiangting, Habibipour Sara, Chou Tom, Yang Otto O

Department of Computational Medicine, UCLA, Los Angeles, CA, United States.

Depts. of Medicine and Microbiology, Immunology, and Molecular Genetics, UCLA, Los Angeles, CA, United States.

ArXiv. 2023 Aug 7:arXiv:2308.03714v1.

Recent studies show that newly sampled monkeypox virus (MPXV) genomes exhibit mutations consistent with Apolipoprotein B mRNA Editing Catalytic Polypeptide-like3 (APOBEC3)-mediated editing, compared to MPXV genomes collected earlier. It is unclear whether these single nucleotide polymorphisms (SNPs) result from APOBEC3-induced editing or are a consequence of genetic drift within one or more MPXV animal reservoirs. We develop a simple method based on a generalization of the General-Time-Reversible (GTR) model to show that the observed SNPs are likely the result of APOBEC3-induced editing. The statistical features allow us to extract lineage information and estimate evolutionary events.

最近的研究表明，与早期收集的猴痘病毒（MPXV）基因组相比，新采样的MPXV基因组表现出与载脂蛋白B信使核糖核酸编辑催化多肽样3（APOBEC3）介导的编辑一致的突变。目前尚不清楚这些单核苷酸多态性（SNP）是由APOBEC3诱导的编辑导致的，还是一个或多个MPXV动物宿主内基因漂移的结果。我们基于通用时间可逆（GTR）模型的推广开发了一种简单方法，以表明观察到的SNP可能是APOBEC3诱导编辑的结果。这些统计特征使我们能够提取谱系信息并估计进化事件。