Holonyak Micro and Nanotechnology Laboratory, The Grainger College of Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States of America.
Department of Bioengineering, The Grainger College of Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, United States of America.
Nanotechnology. 2023 Sep 25;34(49):492002. doi: 10.1088/1361-6528/acf3f0.
The future of medical diagnostics calls for portable biosensors at the point of care, aiming to improve healthcare by reducing costs, improving access, and increasing quality-what is called the 'triple aim'. Developing point-of-care sensors that provide high sensitivity, detect multiple analytes, and provide real time measurements can expand access to medical diagnostics for all. Field-effect transistor (FET)-based biosensors have several advantages, including ultrahigh sensitivity, label-free and amplification-free detection, reduced cost and complexity, portability, and large-scale multiplexing. They can also be integrated into wearable or implantable devices and provide continuous, real-time monitoring of analytes, enabling early detection of biomarkers for disease diagnosis and management. This review analyzes advances in the sensitivity, parallelization, and reusability of FET biosensors, benchmarks the limit of detection of the state of the art, and discusses the challenges and opportunities of FET biosensors for future healthcare applications.
未来的医疗诊断需要在护理点使用便携式生物传感器，旨在通过降低成本、增加医疗服务的可及性和提高医疗质量来改善医疗服务，这被称为“三重目标”。开发能够提供高灵敏度、同时检测多种分析物并提供实时测量的护理点传感器，可以扩大所有人获得医疗诊断的机会。场效应晶体管 (FET) 生物传感器具有许多优点，包括超高灵敏度、无需标记和无需放大检测、降低成本和复杂性、便携性以及大规模多路复用。它们还可以集成到可穿戴或可植入设备中，并对分析物进行连续、实时监测，从而能够早期检测疾病诊断和管理的生物标志物。本文综述分析了 FET 生物传感器在灵敏度、并行化和可重复使用性方面的进展，对现有技术的检测极限进行了基准测试，并讨论了 FET 生物传感器在未来医疗保健应用中的挑战和机遇。
