Gontijo Bruna Rodrigues, Possatti Isabella, Fratelli Caroline Ferreira, Pereira Alexandre Sampaio Rodrigues, Bonasser Larissa Sousa Silva, de Souza Silva Calliandra Maria, Rodrigues da Silva Izabel Cristina
Graduate Program in Health Sciences and Technologies, Faculty of Ceilandia, University of Brasilia, Federal District, Brasilia 72220-900, Brazil.
Graduate Program in Health Sciences, University of Brasilia, Federal District, Brasilia 70910-900, Brazil.
Biomedicines. 2023 Aug 15;11(8):2270. doi: 10.3390/biomedicines11082270.
Major Depressive Disorder (MDD) is a disabling and particularly persistent mental disorder that is considered to be a priority public health problem. The active human dopamine transporter (DAT), which is encoded by the gene, regulates the dopamine concentration in the synaptic cleft. In this sense, this neurotransmitter is primordial in modulating human emotions. This systematic review aims to verify the gene variant's SS (9R/9R) genotype and S (9R) allele frequency fluctuation and its influence on the modulation of pharmacotherapy in MDD. For this purpose, we searched different databases, and after applying the eligibility criteria, six articles were selected. Studies have shown an association between the SS (9R/9R) genotypic and S (9R) allelic presence with the risk of developing MDD, in addition to influencing the decrease in response to antidepressant therapy. However, despite the findings, disagreements were observed between other studies. For this reason, further studies with the () variant in different populations are necessary to understand this polymorphism's role in the onset of this disease.
重度抑郁症（MDD）是一种致残且特别持久的精神障碍，被视为一个优先的公共卫生问题。由该基因编码的活性人类多巴胺转运体（DAT）调节突触间隙中的多巴胺浓度。从这个意义上说，这种神经递质在调节人类情绪方面至关重要。本系统评价旨在验证该基因变体的SS（9R/9R）基因型和S（9R）等位基因频率的波动及其对MDD药物治疗调节的影响。为此，我们检索了不同的数据库，在应用纳入标准后，选择了六篇文章。研究表明，SS（9R/9R）基因型和S（9R）等位基因的存在与患MDD的风险相关，此外还会影响对抗抑郁治疗反应的降低。然而，尽管有这些发现，但其他研究之间仍存在分歧。因此，有必要在不同人群中对该（）变体进行进一步研究，以了解这种多态性在该疾病发病中的作用。
